gene 2,091 words KG: NLGN3
Contents

NLGN3 Gene

🧬 Gene Info
Gene SymbolNLGN3
Full NameNeuroligin-3
ChromosomeXq13.1
Functionencodes a postsynaptic cell adhesion molecule that is essential for the formation, function, and plasticity of synapses throughout the mammalian brain.
Primary Expressionneurons throughout the brain, with particularly high levels in the cerebral cortex, hippocampus, and basal ganglia
Molecular Weight165 kDa
Amino Acids461 aa
Exons19
PathwaysMtor, Neuroprotection, PI3K-mTOR, PI3K-mTOR pathway
UniProt IDQ9NZU4
NCBI Gene ID54413
Ensembl IDENSG00000174373
OMIM300336
GeneCardsNLGN3
Human Protein AtlasNLGN3
Associated DiseasesALS, high-grade gliomas
InteractionsADAM10, BRAIN INJURY, ERK, FAK, Fus, Metalloproteinase
KG Connections59 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (10)

NeuRon Therapeutics
company · KG edge: activates
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: activates
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: inhibits
gnai1 Gene
gene · KG edge: mediates
GNAI3 — G Protein Subunit Alpha I3
gene · KG edge: mediates

Knowledge Graph (12 edges)

NLGN3 activates PI3K-mTOR
neuronal activity regulates NLGN3
ADAM10 activates NLGN3
NLGN3 activates FAK
NLGN3 activates PI3K-mTOR pathway
NLGN3 associated_with high-grade gliomas
ADAM10 regulates NLGN3
neuronal activity activates NLGN3
ADAM10 inhibitors protects_against NLGN3
NLGN3 activates AKT

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