gene 1,732 words KG: GNAI3 2026-03-27
kind:genesection:genesstate:publisheddisease:alzheimers-diseasedisease:parkinsons-diseasepathway:g-protein-signalingpathway:gpcp-signaling
Contents

GNAI3 — G Protein Subunit Alpha I3

🧬 Gene Info
Gene SymbolGNAI3
Full NameG Protein Subunit Alpha I3
AliasesG Protein Alpha i3
Chromosome1p31.3.
FunctionLigand binding to GPCR (e.g., dopamine D2, adenosine A1, muscarinic M2/M4)
Molecular Weight40 kDa
Amino Acids354 aa
UniProt ID[P08754](https://www.uniprot.org/uniprot/P08754)
Ensembl IDENSG00000165197
OMIM616377
GeneCardsGNAI3
Human Protein AtlasGNAI3
Associated DiseasesAls, Ms
InteractionsAKT, AKT1, GNB1, AMPD2, ATG5, MAVS
KG Connections57 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (6)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Tau Protein
protein · KG edge: therapeutic_target
Wnt Signaling in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: therapeutic_target
WIPI1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

GNAI3 expressed_in WIPI1
GNAI3 inhibits IL6
GNAI3 therapeutic_target TAU
GNAI3 therapeutic_target PTEN
GNAI3 associated_with Als
GNAI3 associated_with Ms
GNAI3 associated_with Autophagy
GNAI3 expressed_in Cardiovascular
GNAI3 interacts_with Autophagy
GNAI3 expressed_in Wnt