gene 1,696 words KG: ADAM10
Contents

ADAM10 — A Disintegrin And Metalloproteinase Domain 10

🧬 Gene Info
Gene SymbolADAM10
Full NameA Disintegrin And Metalloproteinase Domain 10
AliasesKuzbanian, CD156c
Chromosome15q21.3
FunctionAlpha-secretase, cleaves APP via non-amyloidogenic pathway
Molecular Weight84.1 kDa
Amino Acids748
PathwaysNon-amyloidogenic APP processing, Notch signaling
UniProt IDO14672
NCBI Gene ID102
Ensembl IDENSG00000137845
OMIM602192
GeneCardsADAM10
Human Protein AtlasADAM10
Protein Length748 amino acids
Associated DiseasesAGING, ALS, Alzheimer, Cancer, Dementia
InteractionsCD44, MTOR, AKT, BACE1, NLGN3, Rb
KG Connections331 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (30)

Soluble TREM2 (sTREM2) as Therapeutic Mimic — Decoupling Pha
Score: 0.45
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (8)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (2)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.46
Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.46

See Also (6)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: co_discussed
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates

Knowledge Graph (12 edges)

ADAM10 regulates Notch pathway
ADAM10 activates NLGN3
ADAM10 regulates NLGN3
ADAM10 co_discussed APP
ADAM10 co_discussed BACE1
ADAM10 co_discussed APOE
ADAM10 co_discussed TNF
ADAM10 co_discussed TREM2
ADAM10 co_discussed APOE4
ADAM10 co_discussed CD33