gene 1,696 words KG: ent-gene-0c9e34cc
Contents

ADAM10 — A Disintegrin And Metalloproteinase Domain 10

🧬 Gene Info
Gene SymbolADAM10
Full NameA Disintegrin And Metalloproteinase Domain 10
AliasesKuzbanian, CD156c
Chromosome15q21.3
FunctionAlpha-secretase, cleaves APP via non-amyloidogenic pathway
Molecular Weight84.1 kDa
Amino Acids748
PathwaysNon-amyloidogenic APP processing, Notch signaling
UniProt IDO14672
NCBI Gene ID102
Ensembl IDENSG00000137845
OMIM602192
GeneCardsADAM10
Human Protein AtlasADAM10
Associated DiseasesAGING, Als, Alzheimer, Cancer, Dementia
InteractionsACAT1, AD, ADAM17, ADAMTS4, AGING, AKT
KG Connections465 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (36)

Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Transglutaminase-2 Cross-Linking Inhibition Strategy
Score: 0.64
Low Complexity Domain Cross-Linking Inhibition
Score: 0.62
SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE-TREM2 Interaction Modulation
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
APOE-Dependent Autophagy Restoration
Score: 0.89
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
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Related Analyses (10)

TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completed
What is the temporal sequence of TREM2 signaling transition
neuroimmunology · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40
Experiment Validation: In vitro ThT Assay
validation · proposed · Score: 0.40

See Also (6)

ABCA7 (Redirect)
redirect · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: co_discussed
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

h-b490c14bf6 targets ent-gene-0c9e34cc
ent-gene-0c9e34cc targeted_by h-b490c14bf6
h-8a1a418d72 targets ent-gene-0c9e34cc
ent-gene-0c9e34cc targeted_by h-8a1a418d72
ent-gene-0c9e34cc participates_in_pathway R-HSA-177929
ent-gene-0c9e34cc participates_in_pathway R-HSA-2122948
ent-gene-0c9e34cc participates_in_pathway R-HSA-2660826
ent-gene-0c9e34cc participates_in_pathway R-HSA-2894862
ent-gene-0c9e34cc participates_in_pathway R-HSA-2644606
ent-gene-0c9e34cc participates_in_pathway R-HSA-2691232

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