gene 1,752 words KG: NOTCH2NLC 2026-03-28
kind:genesection:genestopic:alzheimerstopic:parkinsons
Contents

NOTCH2NLC Gene

🧬 Gene Info
Gene SymbolNOTCH2NLC
Full NameNotch 2 N-terminal-like protein
Chromosome1q12
Protein TypeReceptor
FunctionIn the normal nervous system, Notch signaling regulates critical processes
Gene TypeProtein-coding
PathwaysNOTCH, Notch, Notch signaling, Notch pathway
UniProt IDQ9P0M4
NCBI Gene ID100302521
Ensembl IDENSG00000237289
GeneCardsNOTCH2NLC
Human Protein AtlasNOTCH2NLC
Transcript Length2,451 bp
Associated DiseasesEssential Tremor, Frontotemporal Dementia, Neuronal Intranuclear Inclusion Disease, Parkinson's disease, neurodegeneration
InteractionsNPM1, G3BP1, NLRP3, tyrosine hydroxylase, GENES, AND
KG Connections39 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Phase-Separated Organelle Targeting
Score: 0.52
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

NLRP3 Inflammasome Hypothesis in Parkinson's Disease
hypothesis · KG edge: inhibits
NPM1 Gene
gene · KG edge: activates
NFKBIA Gene (NFKB Inhibitor Alpha)
gene · KG edge: inhibits
G3BP1
gene · KG edge: activates
Genes
index · KG edge: activates

Knowledge Graph (12 edges)

NOTCH2NLC activates NPM1
NOTCH2NLC activates G3BP1
NOTCH2NLC inhibits NLRP3
NOTCH2NLC promotes cell death
NOTCH2NLC promotes α-synuclein
NOTCH2NLC causes neuronal hyperexcitability
NOTCH2NLC inhibits tyrosine hydroxylase
NOTCH2NLC associated_with Neuronal Intranuclear Inclusion Disease
NOTCH2NLC promotes Intranuclear Aggregation
NOTCH2NLC associated_with Essential Tremor