gene 1,193 words KG: NT3 2026-03-24
kind:genesection:genesstate:published
Contents

NT3 Gene

🧬 Gene Info
Gene SymbolNT3
Full NameNeurotrophin 3
Chromosome12p13.31
Protein FamilyNeurotrophin
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe developing and adult CNS: - Hippocampus: Highest expression in dentate gyrus and CA3 region - Cerebral cortex
Amino Acids119 aa
PathwaysPI3K, mTOR, mtor, MAPK
UniProt ID[P20783](https://www.uniprot.org/uniprot/P20783)
Ensembl IDENSG00000185652
GeneCardsNT3
Human Protein AtlasNT3
Associated Diseasesneurodegeneration
InteractionsBDNF, NEPRILYSIN, SIRT1, TRKB, APP, ALZHEIMER
KG Connections25 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (11)

Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: activates
TRKB Gene
gene · KG edge: activates
MECP2 — Methyl-CpG Binding Protein 2
gene · KG edge: activates

Knowledge Graph (12 edges)

NT3 activates BDNF
NT3 activates NEPRILYSIN
NT3 activates SIRT1
NT3 activates TRKB
NT3 activates APP
NT3 activates Als
NT3 activates Ms
NT3 activates Oxidative Stress
NT3 activates Mitochondrial Function
NT3 activates ALZHEIMER