| Gene Symbol | MECP2 |
| Full Name | Methyl-CpG Binding Protein 2 |
| Protein Family | Methyl-CpG binding domain (MBD) family |
| Function | In neurons, MeCP2 binds broadly across the genome, preferentially at methylated CpG dinucleotides and non-CpG methylation sites (particularly mCA), which are highly abundant in mature neurons [@birdse |
| Primary Expression | Cerebral cortex, Hippocampus, Cerebellum, Brainstem, Basal ganglia, Thalamus |
| Subcellular Localization | Nucleus (chromatin-associated) |
| Molecular Weight | 53 kDa |
| Amino Acids | 80 aa |
| Pathways | Akt, Epigenetic, Mapk, Mitophagy |
| UniProt ID | P51608 |
| Ensembl ID | ENSG00000169057 |
| GeneCards | MECP2 |
| Human Protein Atlas | MECP2 |
| Symbol [@preclinical2024]
MECP2 [@vashi2019]
[@lyst2013]
[@chahrour2008]
Full Name [@ramocki2010]
Methyl-CpG Binding Protein 2 [@ncbi]
[@omim]
[@allen]
Chromosome [@allena]
Xq28 [@allenb]
[@brainspan]
[@genes]
NCBI Gene [@proteins]
4204 [@bdnf]
[@httpswwwncbinlmnihgovgene]
[@httpsensemblorghomosapiensgenesummarygensg]
Ensembl [@httpsomimorgentry]
ENSG00000169057 [@httpswwwuniprotorguniprotp]
[@mecp]
[@mecpa]
OMIM | 300005 |
| Associated Diseases | Als, Autism, Epilepsy, Rett syndrome |
| Interactions | SIRT1, JUN, TRKB, BDNF, NRF2, CASP3 |
| KG Connections | 239 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |