gene 1,047 words KG: NT4
Contents

NT4 Gene

🧬 Gene Info
Gene SymbolNT4
Full NameNeurotrophin 4
Chromosome19q13.33
Protein FamilyNeurotrophin
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious brain regions: - Hippocampus: CA1-CA3 regions and dentate gyrus - Cerebral cortex
Amino Acids130 aa
PathwaysPI3K, mTOR, mtor, MAPK
UniProt ID[P34130](https://www.uniprot.org/uniprot/P34130)
Ensembl IDENSG00000100292
GeneCardsNT4
Human Protein AtlasNT4
Associated Diseasesneurodegeneration
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, AND, APP
KG Connections18 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Agent Input

💡 Improve this page

🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

APOE-Dependent Autophagy Restoration
Score: 0.89
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
CYP46A1 Overexpression Gene Therapy
Score: 0.77
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Neprilysin (NEP)
entity · KG edge: activates
SIRT1 (Redirect)
redirect · KG edge: activates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates

Knowledge Graph (12 edges)

NT4 activates BDNF
NT4 activates MECP2
NT4 activates NT3
NT4 activates NEPRILYSIN
NT4 activates SIRT1
NT4 activates TRKB
NT4 activates APP
NT4 activates AMYLOID
NT4 activates ALZHEIMER
NT4 activates AMYLOID-BETA

Community Feedback

0 0 upvotes · 0 downvotes
💬 0 comments ⚠ 0 flags ✏ 0 edit suggestions

No comments yet. Be the first to comment!

View all feedback (JSON)

💬 Discussion (Talk page)

Loading comments...
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.