gene 1,429 words KG: OGT
Contents

OGT — O-GlcNAc Transferase

🧬 Gene Info
Gene SymbolOGT
Full NameO-GlcNAc Transferase
AliasesGene profile: OGT
ChromosomeXq13.1
FunctionOGT catalyzes the transfer of a single GlcNAc from UDP-GlcNAc to the hydroxyl group of serine and threonine residues on target proteins
Primary Expressionneurons and glia:
Molecular Weight110 kDa
Amino Acids016 aa
PathwaysApoptosis, Autophagy, Glycolysis, Immune Response, Inflammasome
UniProt IDO15294
GeneCardsOGT
Human Protein AtlasOGT
Associated Diseasesdepression, neurodegeneration
Known Drugs/CompoundsROS
InteractionsALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AND, APP, ASTROCYTES
SciDEX HypothesesO-GlcNAcylation at T212 competes with phosphorylat
KG Connections144 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

Autophagosome Maturation Checkpoint Control
Score: 0.71
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66

Related Analyses (2)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (13)

Astrocytes
cell · KG edge: activates
ATP P2X3 Receptor Neurons
cell · KG edge: activates
AMPK (AMP-Activated Protein Kinase)
entity · KG edge: regulates
Astrocytes
entity · KG edge: activates
Exosomes
entity · KG edge: regulates

Knowledge Graph (12 edges)

OGT contributes_to chemotherapeutic_resistance
SLC7A11 activates OGT
OGT activates SLC7A11
STX17 activates OGT
OGT activates ULK1
ULK1 activates OGT
OGT regulates CHOP
OGT inhibits RIPK3
OGT inhibits RIPK1
ENO1 regulates OGT

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