| Gene Symbol | SLC7A11 |
| Full Name | Solute Carrier Family 7 Member 11 (xCT) |
| Chromosome | 4q28.3 |
| Protein Type | Transporter |
| Target Class | Transporter |
| Function | Small molecule inhibition of cystine/glutamate exchange |
| Mechanism of Action | Small molecule inhibition of cystine/glutamate exchange |
| Primary Expression | various brain cell types: |
| Druggability | Medium (0.55) |
| Clinical Stage | Approved |
| Pathways | Akt, Autophagy, Epigenetic, Ferroptosis, Glutathione Biosynthesis |
| UniProt ID | Q9UPY5 |
| Ensembl ID | ENSG00000155511 |
| GeneCards | SLC7A11 |
| Human Protein Atlas | SLC7A11 |
| Associated Diseases | ALS, CANCER, CARCINOMA |
| Known Drugs/Compounds | alphaKG, ROS, SORAFENIB, kynurenine, icariin, paricalcitol |
| Interactions | GPX4, SIRT3, NRF2, NCOA4, BECN1, DES |
| SciDEX Target | View Target Profile (4 clinical trials) |
| KG Connections | 1404 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |