gene 866 words KG: PARP2
Contents

PARP2 Gene

🧬 Gene Info
Gene SymbolPARP2
Chromosome14q13.2
Protein TypeGene
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionmost tissues, with high expression in brain regions including the hippocampus, cortex, and cerebellum, where it supports neur
Molecular Weight62 kDa
Amino Acids583 aa
GeneCardsPARP2
Human Protein AtlasPARP2
Exon 15' UTR and start codon
Exons 2-10Coding sequence
Exon 113' UTR with polyadenylation signal
Associated DiseasesALS
InteractionsAGING, ALOX12, DNA, PARP1, TNKS
KG Connections22 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (5)

Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56
CYP46A1 Overexpression Gene Therapy
Score: 0.77
PARP1 Inhibition Therapy
Score: 0.74
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · completed · Score: 0.40

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: inhibits
PARP1 Gene
gene · KG edge: associated_with
PARP3 Gene
gene · KG edge: associated_with
SOX2
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

PARP2 associated_with PARP1
PARP2 associated_with PARP3
PARP2 inhibits TNKS
PARP1 activates PARP2
ALOX12 activates PARP2
PARP2 participates_in ferroptosis
PARP2 inhibits AGING
PARP2 inhibits DNA
PARP2 inhibits Cardiovascular
PARP2 inhibits Diabetes

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