gene 586 words KG: PARP3 2026-03-21
kind:genesection:genesstate:published
Contents

PARP3 Gene

🧬 Gene Info
Gene SymbolPARP3
Full NamePoly(ADP-Ribose) Polymerase 3
Chromosome3p21.2
Protein FamilyPARP family
FunctionPARP3 is primarily involved in:
Primary ExpressionUbiquitous
Molecular Weight60 kDa
Amino Acids583 aa
UniProt IDQ9Y5F4
NCBI Gene ID10039
Ensembl IDENSG00000050767
GeneCardsPARP3
Human Protein AtlasPARP3
Associated Diseasesneurodegeneration
InteractionsTNKS, AGING, DNA
KG Connections17 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
TREM2-mediated microglial tau clearance enhancement
Score: 0.49
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

DNA Damage Repair Deficiency Validation Study in Parkinson's
clinical · proposed · Score: 0.40

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: inhibits
Packard Center for ALS Research
institution · KG edge: inhibits
TNKS Gene
gene · KG edge: inhibits
PARP2 Gene
gene · KG edge: associated_with
PARP1 Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PARP3 associated_with TREM2
PARP3 associated_with OxPC
PARP3 inhibits TNKS
PARP3 inhibits AGING
PARP3 inhibits DNA
PARP3 inhibits Cardiovascular
PARP3 inhibits Diabetes
PARP3 inhibits Aging
PARP3 inhibits Als
PARP3 inhibits Atherosclerosis