gene

TNKS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNKS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
0Analyses
12Outgoing
3Incoming
0Experiments

Summary

TNKS is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in. Associated with Aging, Als, Atherosclerosis. Connected to 16 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info
Gene SymbolTNKS
Full NameTankyrase 1
Chromosome8p23.1.
FunctionAxin PARylation: TNKS PARylates Axin-1 and Axin-2
Primary Expressionvarious brain regions - Higher expression during development - Present in neurons and glial cells - Functions in neuronal develop
Molecular Weight139 kDa
Amino Acids1327 aa
Exons23
PathwaysWnt signaling, Wnt
UniProt IDQ9Y5X5
NCBI Gene ID8658
Ensembl IDENSG00000142208
OMIM607303
GeneCardsTNKS
Human Protein AtlasTNKS
Associated Diseasesneurodegeneration
InteractionsAGING, DNA, PARP2, PARP1, PARP3
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: TNKS — AlphaFold Q9Y5X5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (10)

Knowledge base pages for this entity

Canonical Page

TNKS Gene

gene · 757 words

TNKS2 Protein

protein · 1534 words

PARP in Neurodegeneration

mechanism · 1341 words

PARP2 Gene

gene · 866 words

TNKS Protein

protein · 795 words

TNKS2 Gene

gene · 638 words

Pathway Diagram

graph TD
    TNKS["TNKS"]
    Cardiovascular{"Cardiovascular"}
    TNKS -->|"inhibits"| Cardiovascular
    Diabetes{"Diabetes"}
    TNKS -->|"inhibits"| Diabetes
    Aging{"Aging"}
    TNKS -->|"inhibits"| Aging
    Als{"Als"}
    TNKS -->|"inhibits"| Als
    Atherosclerosis{"Atherosclerosis"}
    TNKS -->|"inhibits"| Atherosclerosis
    Fatty_Liver{"Fatty Liver"}
    TNKS -->|"inhibits"| Fatty_Liver
    Obesity{"Obesity"}
    TNKS -->|"inhibits"| Obesity
    AGING["AGING"]
    TNKS -->|"inhibits"| AGING
    DNA["DNA"]
    TNKS -->|"inhibits"| DNA
    Cholesterol(["Cholesterol"])
    TNKS -->|"inhibits"| Cholesterol
    Dna_Repair(["Dna Repair"])
    TNKS -->|"inhibits"| Dna_Repair
    Lipid_Metabolism(["Lipid Metabolism"])
    TNKS -->|"inhibits"| Lipid_Metabolism
    PARP2["PARP2"]
    PARP2 -->|"inhibits"| TNKS
    PARP1["PARP1"]
    PARP1 -->|"inhibits"| TNKS
    PARP3["PARP3"]
    PARP3 -->|"inhibits"| TNKS

Outgoing (12)

TargetRelationTypeStr
Cardiovascularinhibitsdisease0.65
Diabetesinhibitsdisease0.65
Aginginhibitsdisease0.65
Alsinhibitsdisease0.65
Atherosclerosisinhibitsdisease0.65

Incoming (3)

SourceRelationTypeStr
PARP2inhibitsgene0.60
PARP1inhibitsgene0.60
PARP3inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found