Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TNKS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TNKS is a gene implicated in neurodegeneration research. Key relationships include: inhibits, implicated in. Associated with Aging, Als, Atherosclerosis. Connected to 16 entities in the SciDEX knowledge graph.
| Gene Symbol | TNKS |
| Full Name | Tankyrase 1 |
| Chromosome | 8p23.1. |
| Function | Axin PARylation: TNKS PARylates Axin-1 and Axin-2 |
| Primary Expression | various brain regions - Higher expression during development - Present in neurons and glial cells - Functions in neuronal develop |
| Molecular Weight | 139 kDa |
| Amino Acids | 1327 aa |
| Exons | 23 |
| Pathways | Wnt signaling, Wnt |
| UniProt ID | Q9Y5X5 |
| NCBI Gene ID | 8658 |
| Ensembl ID | ENSG00000142208 |
| OMIM | 607303 |
| GeneCards | TNKS |
| Human Protein Atlas | TNKS |
| Associated Diseases | neurodegeneration |
| Interactions | AGING, DNA, PARP2, PARP1, PARP3 |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TNKS["TNKS"]
Cardiovascular{"Cardiovascular"}
TNKS -->|"inhibits"| Cardiovascular
Diabetes{"Diabetes"}
TNKS -->|"inhibits"| Diabetes
Aging{"Aging"}
TNKS -->|"inhibits"| Aging
Als{"Als"}
TNKS -->|"inhibits"| Als
Atherosclerosis{"Atherosclerosis"}
TNKS -->|"inhibits"| Atherosclerosis
Fatty_Liver{"Fatty Liver"}
TNKS -->|"inhibits"| Fatty_Liver
Obesity{"Obesity"}
TNKS -->|"inhibits"| Obesity
AGING["AGING"]
TNKS -->|"inhibits"| AGING
DNA["DNA"]
TNKS -->|"inhibits"| DNA
Cholesterol(["Cholesterol"])
TNKS -->|"inhibits"| Cholesterol
Dna_Repair(["Dna Repair"])
TNKS -->|"inhibits"| Dna_Repair
Lipid_Metabolism(["Lipid Metabolism"])
TNKS -->|"inhibits"| Lipid_Metabolism
PARP2["PARP2"]
PARP2 -->|"inhibits"| TNKS
PARP1["PARP1"]
PARP1 -->|"inhibits"| TNKS
PARP3["PARP3"]
PARP3 -->|"inhibits"| TNKS| Target | Relation | Type | Str |
|---|---|---|---|
| Cardiovascular | inhibits | disease | 0.65 |
| Diabetes | inhibits | disease | 0.65 |
| Aging | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Atherosclerosis | inhibits | disease | 0.65 |
| Fatty Liver | inhibits | disease | 0.65 |
| Obesity | inhibits | disease | 0.65 |
| AGING | inhibits | gene | 0.60 |
| DNA | inhibits | gene | 0.60 |
| Cholesterol | inhibits | pathway | 0.60 |
| Dna Repair | inhibits | pathway | 0.60 |
| Lipid Metabolism | inhibits | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||