| Gene Symbol | PLEKHG5 |
| Full Name | Pleckstrin Homology And RhoGEF Domain Containing G5 |
| Chromosome | 1p36.31 |
| Protein Family | RhoGEF family |
| Function | PLEKHG5 activates Rho GTPases including RhoA, Rac1, and Cdc42. |
| Primary Expression | the nervous system and is involved in axon guidance and myelination |
| Subcellular Localization | Cytoplasm, Plasma membrane |
| Molecular Weight | 213 kDa |
| Amino Acids | 954 aa |
| Exons | 33 |
| Pathways | NF-κB |
| UniProt ID | Q9Y4L1 |
| GeneCards | PLEKHG5 |
| Human Protein Atlas | PLEKHG5 |
| RhoA | GEF substrate |
| Associated Diseases | Als, Ms, motoneuron_disease |
| Interactions | Rab26, Rac1, AKT, HDAC2, SOD1 |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |