gene 662 words KG: PPP2R2A 2026-03-24
kind:genesection:genesstate:published
Contents

PPP2R2A — Protein Phosphatase 2 Regulatory Subunit B55 Alpha

🧬 Gene Info
Gene SymbolPPP2R2A
Full NameProtein Phosphatase 2 Regulatory Subunit B55 Alpha
Chromosome8p21.2
Functionis a hallmark of Alzheimer's disease and other neurodegenerative disorders, making it a critical therapeutic target [2](https://doi.
Molecular Weight~52 kDa
Amino Acids447 aa
PathwaysMapk
UniProt IDP63151
NCBI Gene ID5520
Ensembl IDENSG00000156535
OMIM601728
GeneCardsPPP2R2A
Human Protein AtlasPPP2R2A
FeatureValue
Protein Length447 amino acids
Associated Diseasesneurodegeneration
InteractionsCAV2, PIK3C3, ERK, CANCER
KG Connections13 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (5)

Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.51
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.48
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed

See Also (8)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: activates
erk-mapk-signaling-neurodegeneration
mechanism · KG edge: inhibits
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: regulates
Packard Center for ALS Research
institution · KG edge: activates
PIK3C3 — Phosphatidylinositol 3-Kinase Catalytic Subuni
gene · KG edge: activates

Knowledge Graph (12 edges)

PPP2R2A activates CAV2
PPP2R2A activates PIK3C3
PPP2R2A regulates CANCER
PPP2R2A activates Als
PPP2R2A regulates Aging
PPP2R2A regulates Cancer
PPP2R2A activates Mapk
PPP2R2A inhibits Tumor
PPP2R2A inhibits Cancer
PP2A regulates PPP2R2A