PIK3C3

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIK3C3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

PIK3C3 (VPS34) is the catalytic subunit of the class III phosphatidylinositol 3-kinase (PI3K-III), essential for autophagy initiation, endosomal trafficking, lysosomal function, and cellular clearance of protein aggregates in neurodegenerative diseases.

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flowchart TD
    PIK3C3(["PIK3C3"])
    BECN1(["BECN1"])
    Sertoli_Cell["/"Sertoli Cell"/"]
    AUTOPHAGY["AUTOPHAGY"]
    Sertoli_Cell_Polarity("Sertoli Cell Polarity")
    autophagy["autophagy"]
    PARKINSON_S_DISEASE(["PARKINSON'S DISEASE"])
    Spautin_1["Spautin-1"]
    CLU(["CLU"])
    SCIN(["SCIN"])
    BRSK2(["BRSK2"])
    SRSF1(["SRSF1"])
    NRBF2(["NRBF2"])
    Autophagy["Autophagy"]

    BECN1 -->|"associated with"| PIK3C3
    PIK3C3 -->|"expressed in"| Sertoli_Cell
    PIK3C3 -->|"regulates"| AUTOPHAGY
    PIK3C3 -->|"associated with"| Sertoli_Cell_Polarity
    PIK3C3 -->|"activates"| autophagy
    PIK3C3 -->|"associated with"| PARKINSON_S_DISEASE
    PIK3C3 -->|"regulates"| Sertoli_Cell_Polarity
    Spautin_1 -->|"associated with"| PIK3C3
    CLU -->|"activates"| PIK3C3
    PIK3C3 -->|"associated with"| SCIN
    PIK3C3 -->|"associated with"| Sertoli_Cell
    BRSK2 -->|"associated with"| PIK3C3
    SRSF1 -->|"binds"| PIK3C3
    NRBF2 -->|"participates in"| PIK3C3
    PIK3C3 -->|"regulates"| Autophagy

    style PIK3C3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0