gene 1,713 words KG: PQBP1 2026-03-28
kind:genesection:genesstate:publishedtopic:alzheimerstopic:parkinsons
Contents

PQBP1 Gene - Polyglutamine Binding Protein 1

🧬 Gene Info
Gene SymbolPQBP1
Functionencodes a small nuclear protein that specifically binds to polyglutamine (polyQ) tracts found in various disease proteins.
Subcellular LocalizationNuclear
Molecular Weight37 kDa
Amino Acids312 aa
PathwaysImmune Response
Ensembl IDENSG00000102172
GeneCardsPQBP1
Human Protein AtlasPQBP1
Molecular weight~37 kDa
Subcellular localizationNuclear
Domain structureWW domain, polyQ-binding region
Associated DiseasesAls, neurodegeneration
InteractionsCGAS, STING, VCP, NEURODEGENERATIVE DISORDERS, INFLAMMATION, BRAIN INFLAMMATION
KG Connections27 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
PARP1 Inhibition Therapy
Score: 0.58
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45

Related Analyses (8)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (9)

Tau Protein
protein · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
cGAS-STING Pathway Dysregulation Hypothesis in Parkinso
hypothesis · KG edge: activates
STING Gene
gene · KG edge: activates
CGAS Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

PQBP1 activates CGAS
PQBP1 activates STING
PQBP1 associated_with STING
PQBP1 associated_with neurodegeneration
PQBP1 interacts_with VCP
PQBP1 activates NEURODEGENERATIVE DISORDERS
PQBP1 activates INFLAMMATION
PQBP1 activates BRAIN INFLAMMATION
PQBP1 activates GENES
PQBP1 activates CGAS-STING