| Gene Symbol | CGAS |
| Chromosome | 6q15 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | Small molecule inhibitor of cyclic dinucleotide synthesis |
| Mechanism of Action | Small molecule inhibitor of cyclic dinucleotide synthesis |
| Druggability | Medium (0.47) |
| Clinical Stage | Phase III |
| Molecular Weight | 57 kDa |
| Amino Acids | 522 aa |
| Exons | 8 |
| Pathways | Akt, Amyloid, Apoptosis, Autophagy, Calcium Signaling |
| UniProt ID | Q8N884 |
| NCBI Gene ID | 115004 |
| Ensembl ID | ENSG00000154122 |
| GeneCards | CGAS |
| Human Protein Atlas | CGAS |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis |
| Known Drugs/Compounds | Aberrant DNA, RAPAMYCIN, cGAS Inhibitors, Ginkgetin, Mitochondrial DNA, Mitochondrial Dna |
| Interactions | STING1, DNASE2, PARP1, IRF3, SQSTM1, RPS6KB1 |
| SciDEX Target | View Target Profile (4 clinical trials) |
| KG Connections | 1914 knowledge graph edges |
| Databases | GeneCardsHPASTRING |