gene 587 words KG: PRDM2 2026-03-24
kind:genesection:genesstate:published
Contents

PRDM2 — PR/SET domain 2

🧬 Gene Info
Gene SymbolPRDM2
Full NamePRDI-BF1 and RIZ Homology Domain Containing 2
Protein FamilyPRDM Family
Protein TypeTransferase
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular LocalizationNucleus
Molecular Weight59 kDa
UniProt IDQ15691
GeneCardsPRDM2
Human Protein AtlasPRDM2
Alzheimer's DiseaseAltered expression and function contributes to epigenetic dysregulation of neuronal survival genes
Parkinson's DiseaseMay affect dopaminergic neuron survival through transcriptional mechanisms
Huntington's DiseaseInvolved in transcriptional dysregulation caused by mutant huntingtin protein
Associated Diseasesneurodegeneration
KG Connections14 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Dual-Domain Antibodies with Engineered Fc-FcRn Affinity Modu
Score: 0.57
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.46
Glycine-Rich Domain Competitive Inhibition
Score: 0.43
Low Complexity Domain Cross-Linking Inhibition
Score: 0.42

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · completed

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (10)

Wnt Signaling in Neurodegeneration
mechanism · KG edge: expressed_in
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: expressed_in
PI3K — Phosphoinositide 3-Kinase
gene · KG edge: expressed_in
EP300 Gene
gene · KG edge: contributes_to
ASH1L
gene · KG edge: contributes_to

Knowledge Graph (12 edges)

PRDM2 contributes_to EP300
PRDM2 expressed_in DNA
PRDM2 expressed_in P53
PRDM2 expressed_in CANCER
PRDM2 contributes_to GENES
PRDM2 expressed_in Colorectal Cancer
PRDM2 expressed_in Cancer
PRDM2 expressed_in Tumor
PRDM2 expressed_in Mapk
PRDM2 expressed_in Mismatch Repair