gene 988 words KG: ASH1L 2026-03-22
kind:genesection:genesstate:published
Contents

ASH1L

🧬 Gene Info
Gene SymbolASH1L
Chromosome1q22
Protein TypeTransferase
FunctionHistone H3K36 methyltransferase
Amino Acids2964 aa
Exons28
Gene TypeProtein-coding
PathwaysMapk, Mismatch Repair, Wnt, Epigenetic
NCBI Gene ID55870
Ensembl IDENSG00000116539
GeneCardsASH1L
Human Protein AtlasASH1L
HGNC ID876
ProteinASH1L protein
Key DomainsAWS, SET, Post-SET, PHD, BAH, Bromodomain
Associated DiseasesFibrosis, Tourette syndrome
InteractionsNME1, MMP, Ras, ASH1L-AS1
KG Connections30 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (11)

KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.38
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
PARP1 Inhibition Therapy
Score: 0.58
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

Related Analyses (2)

Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: expressed_in
PRDM2 — PR/SET domain 2
gene · KG edge: contributes_to
PI3K — Phosphoinositide 3-Kinase
gene · KG edge: expressed_in
NME1 - NME Nucleoside Diphosphate Kinase 1
gene · KG edge: activates
EP300 Gene
gene · KG edge: contributes_to

Knowledge Graph (12 edges)

ASH1L activates NME1
ASH1L inhibits MMP
ASH1L associated_with Tourette syndrome
ASH1L upregulates STAC2
ASH1L inhibits osteoclastogenesis
ASH1L inhibits miR-let-7b
ASH1L catalyzes H3K36me
ASH1L catalyzes H3K4me
ASH1L upregulates IGF-2
ASH1L contributes_to ARID1A