gene 1,043 words KG: ARID1A 2026-03-22
kind:genesection:genesstate:published
Contents

ARID1A

🧬 Gene Info
Gene SymbolARID1A
Chromosome1p36.11
FunctionBAF chromatin remodeling complex subunit
Exons20
Gene TypeProtein-coding
PathwaysApoptosis, Dna Repair, Epigenetic, Immunotherapy, Mtor
NCBI Gene ID8289
Ensembl IDENSG00000117713
GeneCardsARID1A
Human Protein AtlasARID1A
HGNC ID11110
ProteinARID1A protein
Key DomainsARID, DUF3518, nuclear localization signal
Disease AssociationsAlzheimer's disease, Coffin-Siris syndrome, intellectual disability
Numerous LoF variantsTruncating
Associated DiseasesAls, BREAST CANCER, CANCER, Carcinoma
InteractionsATR, RNASEH2B, TREX1, CD8, STING, SMARCA4
KG Connections195 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Knowledge Graph

Related Hypotheses (7)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
APOE-Dependent Autophagy Restoration
Score: 0.61
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.48
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.38

Related Analyses (3)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Epigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: associated_with
ATR Gene
gene · KG edge: inhibits
APC Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

ARID1A associated_with PTEN
ARID1A associated_with PIK3CA
ARID1A associated_with TP53
ARID1A expressed_in PI3K
ARID1A contributes_to PRDM2
ARID1A contributes_to EP300
ARID1A treats POLE
ARID1A expressed_in L1CAM
ARID1A expressed_in AKT
ARID1A expressed_in MTOR