gene

ARID1A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARID1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

195Connections

0Hypotheses

0Analyses

50Outgoing

31Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ARID1A
Chromosome	1p36.11
Function	BAF chromatin remodeling complex subunit
Exons	20
Gene Type	Protein-coding
Pathways	Apoptosis, Dna Repair, Epigenetic, Immunotherapy, Mtor
NCBI Gene ID	8289
Ensembl ID	ENSG00000117713
GeneCards	ARID1A
Human Protein Atlas	ARID1A
HGNC ID	11110
Protein	ARID1A protein
Key Domains	ARID, DUF3518, nuclear localization signal
Disease Associations	Alzheimer's disease, Coffin-Siris syndrome, intellectual disability
Numerous LoF variants	Truncating
Associated Diseases	Als, BREAST CANCER, CANCER, Carcinoma
Interactions	ATR, RNASEH2B, TREX1, CD8, STING, SMARCA4
KG Connections	195 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ARID1A["ARID1A"] -->|"associated"| Tumor["Tumor"]
    style Tumor fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ARID1A["ARID1A"] -->|"associated"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ARID1A["ARID1A"] -->|"upstream of"| cytosolic_ssDNA["cytosolic ssDNA"]
    style cytosolic_ssDNA fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    ARID1A["ARID1A"] -->|"associated"| KRAS["KRAS"]
    style KRAS fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ARID1A["ARID1A"] -->|"associated"| GENES["GENES"]
    style GENES fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ARID1A["ARID1A"] -->|"associated"| Ovarian_Cancer["Ovarian Cancer"]
    style Ovarian_Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ARID1A["ARID1A"] -->|"associated"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PTEN["PTEN"] -->|"associated"| ARID1A["ARID1A"]
    style PTEN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PIK3CA["PIK3CA"] -->|"associated"| ARID1A["ARID1A"]
    style PIK3CA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    TP53["TP53"] -->|"associated"| ARID1A["ARID1A"]
    style TP53 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FBXW7["FBXW7"] -->|"associated"| ARID1A["ARID1A"]
    style FBXW7 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CANCER["CANCER"] -->|"therapeutic target"| ARID1A["ARID1A"]
    style CANCER fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style ARID1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (164)

Target	Relation	Type	Str
Tumor	associated_with	disease	1.00
cytosolic ssDNA	upstream_of	phenotype	0.95
Cancer	associated_with	disease	0.95
CANCER	associated_with	gene	0.90
Cancer	activates	disease	0.85
Tumor	activates	disease	0.85
KRAS	associated_with	gene	0.80
GENES	associated_with	gene	0.80
Cancer	expressed_in	disease	0.75
Tumor	expressed_in	disease	0.75
Cancer	regulates	disease	0.75
Ovarian Cancer	associated_with	disease	0.75
Als	associated_with	disease	0.75
PIK3CA	associated_with	gene	0.70
TP53	associated_with	gene	0.70
PI3K	expressed_in	gene	0.70
CTNNB1	associated_with	gene	0.70
GENES	contributes_to	gene	0.70
DNA	regulates	gene	0.70
Immune Checkpoint	inhibits	pathway	0.70
DNA	associated_with	gene	0.70
Epigenetic	regulates	pathway	0.70
CANCER	causes	disease	0.70
Hepatocellular Carcinoma	risk_factor_for	disease	0.68
Carcinoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Colorectal Cancer	expressed_in	disease	0.65
Cancer	treats	disease	0.65
Als	treats	disease	0.65
Tumor	inhibits	disease	0.65
Als	regulates	disease	0.65
Gastric Cancer	inhibits	disease	0.65
Carcinoma	associated_with	disease	0.65
Breast Cancer	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Pancreatic Cancer	associated_with	disease	0.65
Prostate Cancer	activates	disease	0.65
Inflammation	activates	disease	0.65
Cancer	contributes_to	disease	0.65
Renal Cell Carcinoma	contributes_to	disease	0.65
Carcinoma	contributes_to	disease	0.65
Als	contributes_to	disease	0.65
Colorectal Cancer	associated_with	disease	0.65
Gastric Cancer	associated_with	disease	0.65
Als	inhibits	disease	0.65
Aging	activates	disease	0.65
Aging	encodes	disease	0.65

Incoming (31)

Source	Relation	Type	Str
PTEN	associated_with	gene	0.90
PIK3CA	associated_with	gene	0.60
TP53	associated_with	gene	0.60
SMARCA4	interacts_with	gene	0.60
ASH1L	contributes_to	gene	0.60
FGFR3	associated_with	gene	0.60
PTEN	contributes_to	gene	0.60
BAX	regulates	gene	0.60
BRAF	associated_with	gene	0.60
TGFBR2	regulates	gene	0.60
CD8	activates	gene	0.60
CDKN2A	activates	gene	0.60
APC	associated_with	gene	0.60
PMS2	activates	gene	0.60
CACNA1G	activates	gene	0.60
CDKN2A	encodes	gene	0.60
MLH1	activates	gene	0.60
NEUROG1	activates	gene	0.60
FBXW7	associated_with	gene	0.60
CANCER	therapeutic_target	gene	0.60
KRAS	activates	gene	0.60
P53	activates	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CANCER	expressed_in	gene	0.60
APOPTOSIS	regulates	gene	0.60
CANCER	regulates	gene	0.60
GENES	interacts_with	gene	0.60
DNA	associated_with	gene	0.60
ALK	associated_with	gene	0.60
ATEZOLIZUMAB	associated_with	drug	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ARID1A

Understanding Entity Pages

Wiki Pages (21)

ARID1A

Histone Modification Pathways in Neurodegeneration

Chromatin Remodeling in Neurodegeneration

SMARCA2 (BRM)

Epigenetics in Parkinson's Disease

PMS2 — DNA Mismatch Repair Protein PMS2

Section 200: Epigenetic and Chromatin Therapy in CBS/PSP

SMARCA2 Protein (BAF155)

NEUROG1 (Neurogenin-1)

Section 192 Advanced Epigenomics and Chromatin Therapy in CBS/PSP

SMARCA4

ARID1B

ARID2 (AT-Rich Interaction Domain 2)

ASH1L

RNASEH2B — Ribonuclease H2 Subunit B

UBE2K Gene

BRG1 Gene

ARID1A Protein

PRDM2 — PR/SET domain 2

PRDM2 Histone Methyltransferase (PRDM2)

Proteins

Pathway Diagram

Outgoing (164)

Incoming (31)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)