gene 503 words KG: RNF14 2026-03-21
kind:genesection:genesstate:published
Contents

RNF14 — Ring Finger Protein 14

🧬 Gene Info
Gene SymbolRNF14
Full NameRing Finger Protein 14 (ARA54)
Chromosome5q23.3
Protein TypeLigase
Functionis a gene located on chromosome 5q23.
Primary ExpressionUbiquitously expressed; high expression in brain, testis, prostate
Amino Acids511 aa
Exons12
Pathwaysubiquitin-proteasome
UniProt IDQ9Y2X9
NCBI Gene ID9744
Ensembl IDENSG00000082630
OMIM605423
GeneCardsRNF14
Human Protein AtlasRNF14
Associated DiseasesALS, Aging, Alzheimer
InteractionsUBIQUITIN, CCT4, ULK2, STXBP3, SORL1, SFPQ
KG Connections89 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (2)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (10)

IGF2R Protein
protein · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with

Knowledge Graph (12 edges)

RNF14 associated_with UBIQUITIN
RNF14 activates UBIQUITIN
RNF14 associated_with EEF1A
RNF14 associated_with ULK2
RNF14 associated_with SSBP1
RNF14 associated_with SYNCRIP
RNF14 associated_with STXBP3
RNF14 associated_with IGF2R
RNF14 associated_with IDS
RNF14 associated_with SORL1