gene

CALB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

142Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

CALB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Alzheimer, Inflammation, Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCALB1
Chromosome8q21.3
Protein TypeGene
Functionis a gene located on chromosome 8q21.
Primary Expressionselect neuronal populations throughout the central and peripheral nervous systems, including cerebellar Purkinje cells, hippocampal interneurons and p
Molecular Weight30 kDa
Amino Acids261 aa
Exons9
PathwaysMapk
UniProt IDP05937
NCBI Gene ID793
GeneCardsCALB1
Human Protein AtlasCALB1
TaxonomyID
Cell Ontology (CL)CL:0000745
Associated DiseasesALS, Alzheimer, Inflammation, Ms
InteractionsPVALB, S100B, GFAP, NTRK2, MAPK1, NTRK3
KG Connections142 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CALB1 — AlphaFold P05937 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Horizontal Cells (Retina)

cell · 806 words

calcium-dysregulation-comparison

mechanism · 6468 words

substantia-nigra

brain_region · 4437 words

Excitotoxicity Pathway

mechanism · 3424 words

Calcium Dysregulation to Excitotoxicity Pathway

mechanism · 3206 words

Calcium Dysregulation in Neurodegenerative Diseases

mechanism · 3170 words

Pathway Diagram

graph TD
    CALB1["<b>CALB1</b>"]
    Alzheimer{"Alzheimer"}
    CALB1 -->|"associated with"| Alzheimer
    Ms{"Ms"}
    CALB1 -->|"associated with"| Ms
    Inflammation{"Inflammation"}
    CALB1 -->|"associated with"| Inflammation
    KCNN3["KCNN3"]
    CALB1 -->|"associated with"| KCNN3
    GRIN2B["GRIN2B"]
    CALB1 -->|"associated with"| GRIN2B
    CAV1["CAV1"]
    CALB1 -->|"associated with"| CAV1
    GAIN["GAIN"]
    CALB1 -->|"associated with"| GAIN
    CACNA1C["CACNA1C"]
    CALB1 -->|"associated with"| CACNA1C
    Calcium_Signaling(["Calcium Signaling"])
    CALB1 -->|"associated with"| Calcium_Signaling
    neurodegeneration["neurodegeneration"]
    CALB1 -->|"implicated in"| neurodegeneration
    style CALB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (87)

TargetRelationTypeStr
Alzheimerassociated_withdisease0.65
Msassociated_withdisease0.65
Inflammationassociated_withdisease0.65
Neurodegenerationexpressed_indisease0.65
Alsassociated_withdisease0.65

Incoming (55)

SourceRelationTypeStr
SLC17A7biomarker_forgene0.60
RAB7expressed_ingene0.60
AKTexpressed_ingene0.60
RAB5expressed_ingene0.60
CACNA1Gbiomarker_forgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found