gene 1,101 words KG: CCT4
Contents

CCT4 Gene

🧬 Gene Info
Gene SymbolCCT4
Full NameChaperonin Containing TCP1 Subunit 4 (Delta)
Chromosome2p15
Protein TypeChaperone
Molecular Weight~58 kDa
Amino Acids539 aa
Exons12
UniProt IDP50991
NCBI Gene ID10382
Ensembl IDENSG00000108771
OMIM605588
GeneCardsCCT4
Human Protein AtlasCCT4
Protein Length539 amino acids
CCT enhancersIncrease chaperone activity
Associated DiseasesALS, Alzheimer
InteractionsULK2, STXBP3, SORL1, SFPQ, IGF2R, IDS
KG Connections67 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51

Related Analyses (6)

APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed

Related Experiments (19)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40
s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40
s:** - Temporal analysis showing mitochondrial defects prece
falsification · proposed · Score: 0.40
Proposed experiment from debate on TDP-43 undergoes liquid-l
falsification · proposed · Score: 0.40
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau
clinical · proposed · Score: 0.40

See Also (15)

UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses
remternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypotheses
nct05508789
clinical_trial · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypotheses

Knowledge Graph (12 edges)

CCT4 associated_with CALB1
CCT4 associated_with SORL1
CCT4 associated_with IGF2R
CCT4 associated_with STXBP3
CCT4 associated_with RNF14
CCT4 associated_with SFPQ
CCT4 associated_with SMARCB1
CCT4 associated_with SYNE2
CCT4 interacts_with ULK2
CCT4 interacts_with STXBP3