gene 2,231 words KG: RNF5 2026-03-26
kind:genesection:genesstate:published
Contents

RNF5 — RING Finger Protein 5

🧬 Gene Info
Gene SymbolRNF5
Full NameRING Finger Protein 5
Chromosome6p21.33
Protein FamilyRING finger E3 ubiquitin ligase family
Protein TypeLigase
Functionis a RING-type E3 ubiquitin ligase localized primarily to the endoplasmic reticulum (ER) membrane.
Primary Expressionvirtually all human tissues with highest levels in: - Brain: Cerebral cortex, hippocampus, substantia nigra, cerebellum - Heart: Myocardium, c
Amino Acids180 aa
Exons4
PathwaysImmune Response
UniProt ID[Q99969](https://www.uniprot.org/uniprot/Q99969)
Ensembl IDENSG00000243156
OMIM603419
GeneCardsRNF5
Human Protein AtlasRNF5
Associated Diseasesneurodegeneration
KG Connections24 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (5)

Astroglial Gap Junction Coordination via Connexin-43 Phospho
Score: 0.50
Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.45
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.41
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (6)

Mitochondrial transfer between neurons and glia
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (12)

Ubiquitin
protein · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: therapeutic_target
NBR1 Gene
gene · KG edge: contributes_to
MAVS Gene
gene · KG edge: contributes_to
LRPPRC — Leucine-Rich Pentatricopeptide Repeat Containi
gene · KG edge: therapeutic_target

Knowledge Graph (12 edges)

RNF5 contributes_to NBR1
RNF5 regulates BRCA1
RNF5 regulates CFTR
RNF5 associated_with UBIQUITIN
RNF5 contributes_to AUTOPHAGY
RNF5 contributes_to Autophagy
RNF5 regulates Immune Response
RNF5 regulates Fibrosis
RNF5 expressed_in Tumor
RNF5 therapeutic_target Colorectal Cancer