gene 1,739 words KG: MAVS 2026-03-26
kind:genesection:genesstate:published
Contents

MAVS Gene

🧬 Gene Info
Gene SymbolMAVS
Full NameMitochondrial Antiviral Signaling Protein
Chromosome20p13
Protein TypeAdaptor Protein
Functionencodes a critical adaptor protein that serves as the central hub for Rig-I-like receptor (RLR) signaling in the innate immune response.
Primary ExpressionUbiquitous (liver, heart, brain)
Amino Acids540 aa
PathwaysNF-κB
UniProt IDQ9Y2H9
NCBI Gene ID57468
Ensembl IDENSG00000088888
OMIM609588
GeneCardsMAVS
Human Protein AtlasMAVS
Associated DiseasesAging, Infection, Inflammation
Known Drugs/Compoundsrapamycin
InteractionsFIP200, AMBRA1, APC, RIPK1, MLST8, HMGB1
KG Connections552 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (11)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
APOE-Dependent Autophagy Restoration
Score: 0.61
Microbial Inflammasome Priming Prevention
Score: 0.58
Phase-Separated Organelle Targeting
Score: 0.52
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
ATG5 — Autophagy Related 5
gene · KG edge: interacts_with
ATG16L1 - Autophagy Related 16 Like 1
gene · KG edge: interacts_with
ATF6 - Activating Transcription Factor 6
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

MAVS interacts_with FIP200
MAVS interacts_with AMBRA1
MAVS interacts_with APC
MAVS interacts_with RIPK1
MAVS interacts_with MLST8
MAVS interacts_with HMGB1
MAVS interacts_with STAT3
MAVS interacts_with STING1
MAVS interacts_with LRRK2
MAVS interacts_with EGFR