Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Fibroblast: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Fibroblast is a cell type relevant to neurodegeneration research. Key relationships include: expressed in, associated with. Connected to 164 entities in the SciDEX knowledge graph.
| Cell Type | Fibroblast |
| Related Genes | PPAR, IL-1, IL-17, PIEZO, YTHDF1, BLM |
| Linked Hypotheses | 119 hypotheses |
Knowledge base pages for this entity
graph TD
MICROTUBULES["MICROTUBULES"] -->|"expressed in"| Fibroblast["Fibroblast"]
MAP6["MAP6"] -->|"expressed in"| Fibroblast["Fibroblast"]
TAU["TAU"] -->|"expressed in"| Fibroblast["Fibroblast"]
ROS["ROS"] -->|"expressed in"| Fibroblast["Fibroblast"]
style Fibroblast fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Myofibroblast | associated_with | cell_type | 0.85 |
| ENDOTHELIAL | associated_with | concept | 0.50 |
| T CELLS | associated_with | concept | 0.50 |
| PERICYTES | associated_with | concept | 0.50 |
| ENDOTHELIAL CELLS | associated_with | concept | 0.50 |
| FIBROBLASTS | associated_with | concept | 0.50 |
| B CELLS | associated_with | concept | 0.50 |
| PDGF | activates | concept | 0.50 |
| FIBROBLASTS | interacts_with | concept | 0.50 |
| GLUT4 | activates | concept | 0.50 |
| GLUCOSE METABOLISM | activates | concept | 0.50 |
| INSULIN | interacts_with | concept | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| disease | interacts_with | disease | 0.50 |
| GENE EXPRESSION | interacts_with | concept | 0.50 |
| Rheumatoid Arthritis | interacts_with | disease | 0.50 |
| Pain | interacts_with | disease | 0.50 |
| FIBROBLASTS | expressed_in | concept | 0.50 |
| NEURONS | interacts_with | concept | 0.50 |
| Sepsis | associated_with | disease | 0.50 |
| Pi3K/Akt | activates | pathway | 0.50 |
| Pulmonary Fibrosis | activates | disease | 0.50 |
| PI3K/AKT/mTOR | activates | pathway | 0.50 |
| disease | activates | disease | 0.50 |
| FIBROBLASTS | activates | concept | 0.50 |
| MTOR SIGNALING | activates | concept | 0.50 |
| Rheumatoid Arthritis | associated_with | disease | 0.50 |
| Pancreatic Cancer | inhibits | disease | 0.50 |
| Reactive Oxygen Species | interacts_with | process | 0.50 |
| EXTRACELLULAR MATRIX | interacts_with | concept | 0.50 |
| CHRONIC INFLAMMATION | interacts_with | concept | 0.50 |
| disease | expressed_in | disease | 0.50 |
| Spinocerebellar Ataxia | expressed_in | disease | 0.50 |
| ALZHEIMER'S | expressed_in | concept | 0.50 |
| PARKINSON'S | expressed_in | concept | 0.50 |
| FRONTOTEMPORAL | expressed_in | concept | 0.50 |
| HUNTINGTON'S | expressed_in | concept | 0.50 |
| STAU1 | expressed_in | concept | 0.50 |
| CELL PROLIFERATION | activates | concept | 0.50 |
| Tgf-Β Signaling | activates | pathway | 0.50 |
| Rheumatoid Arthritis | protects_against | disease | 0.50 |
| NEURONS | inhibits | concept | 0.50 |
| FIBROBLASTS | inhibits | concept | 0.50 |
| NEURONS | activates | concept | 0.50 |
| NEURONS | associated_with | concept | 0.50 |
| Hippocampus | expressed_in | brain_region | 0.50 |
| Cerebellum | expressed_in | brain_region | 0.50 |
| Cortex | expressed_in | brain_region | 0.50 |
| Striatum | expressed_in | brain_region | 0.50 |
| Spinal Cord | expressed_in | brain_region | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PHAGOCYTOSIS | activates | gene | 0.60 |
| ALZHEIMER | activates | gene | 0.60 |
| COMPLEMENT | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| DEMENTIA | activates | gene | 0.60 |
| SPP1 | activates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| GRN | activates | gene | 0.60 |
| CTSB | activates | gene | 0.60 |
| C1QA | activates | gene | 0.60 |
| MICROTUBULES | regulates | gene | 0.60 |
| TAU | regulates | gene | 0.60 |
| MAP6 | regulates | gene | 0.60 |
| BAD | regulates | gene | 0.60 |
| DAG1 | regulates | gene | 0.60 |
| ROS | regulates | gene | 0.60 |
| IGF1R | regulates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| HSPG2 | regulates | gene | 0.60 |
| KCNK2 | associated_with | gene | 0.60 |
| WNT | associated_with | gene | 0.60 |
| SCN1A | associated_with | gene | 0.60 |
| KCNQ1 | associated_with | gene | 0.60 |
| TRPA1 | associated_with | gene | 0.60 |
| SCN5A | associated_with | gene | 0.60 |
| CACNA1B | associated_with | gene | 0.60 |
| TRPV1 | associated_with | gene | 0.60 |
| PIEZO2 | associated_with | gene | 0.60 |
| KCNN4 | associated_with | gene | 0.60 |
| HIPPO | associated_with | gene | 0.60 |
| SCNN1A | associated_with | gene | 0.60 |
| CFTR | associated_with | gene | 0.60 |
| AXON | associated_with | gene | 0.60 |
| TRPM7 | associated_with | gene | 0.60 |
| KCNMA1 | associated_with | gene | 0.60 |
| APOE3 | activates | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| APOE4 | activates | gene | 0.60 |
| LYSOSOME | regulates | gene | 0.60 |
| TRPML2 | regulates | gene | 0.60 |
| TRPML1 | regulates | gene | 0.60 |
| AUTOPHAGY | associated_with | gene | 0.60 |
| MCOLN1 | regulates | gene | 0.60 |
| JUN | regulates | gene | 0.60 |
| TRPML3 | regulates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| LYSOSOME | activates | gene | 0.60 |
| NRF1 | therapeutic_target | gene | 0.60 |
| SIRT1 | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-06 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||