Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about cardiomyopathy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
graph TD
cardiomyopathy["<b>cardiomyopathy</b>"]
UQCRFS1["UQCRFS1"]
cardiomyopathy -->|"interacts with"| UQCRFS1
FIBROBLASTS["FIBROBLASTS"]
cardiomyopathy -->|"associated with"| FIBROBLASTS
BMAL1["BMAL1"]
cardiomyopathy -->|"activates"| BMAL1
BCL2["BCL2"]
cardiomyopathy -->|"activates"| BCL2
ACSL4["ACSL4"]
cardiomyopathy -->|"inhibits"| ACSL4
mTOR["mTOR"]
cardiomyopathy -->|"inhibits"| mTOR
AMPK["AMPK"]
cardiomyopathy -->|"inhibits"| AMPK
ferroptosis["ferroptosis"]
cardiomyopathy -->|"inhibits"| ferroptosis
Microrna["Microrna"]
cardiomyopathy -->|"inhibits"| Microrna
MTOR_SIGNALING["MTOR SIGNALING"]
cardiomyopathy -->|"inhibits"| MTOR_SIGNALING
ferroptosis["ferroptosis"]
cardiomyopathy -->|"associated with"| ferroptosis
CELL_DEATH["CELL DEATH"]
cardiomyopathy -->|"associated with"| CELL_DEATH
cancer["cancer"]
cardiomyopathy -->|"activates"| cancer
ferroptosis["ferroptosis"]
cardiomyopathy -->|"activates"| ferroptosis
Cardiac["Cardiac"]
cardiomyopathy -->|"activates"| Cardiac
BLOOD_BRAIN_BARRIER["BLOOD-BRAIN BARRIER"]
cardiomyopathy -->|"activates"| BLOOD_BRAIN_BARRIER
disease["disease"]
cardiomyopathy -->|"activates"| disease
Myocardial_Infarction["Myocardial Infarction"]
cardiomyopathy -->|"activates"| Myocardial_Infarction
Chronic_Kidney_Disease["Chronic Kidney Disease"]
cardiomyopathy -->|"activates"| Chronic_Kidney_Disease
Retinopathy["Retinopathy"]
cardiomyopathy -->|"activates"| Retinopathy
LMNA["LMNA"]
cardiomyopathy -->|"activates"| LMNA
PDGF["PDGF"]
cardiomyopathy -->|"activates"| PDGF
LMNA["LMNA"]
cardiomyopathy -->|"interacts with"| LMNA
Genes["Genes"]
cardiomyopathy -->|"interacts with"| Genes
Cardiac["Cardiac"]
cardiomyopathy -->|"interacts with"| Cardiac
disease["disease"]
cardiomyopathy -->|"associated with"| disease
DIABETES["DIABETES"]
cardiomyopathy -->|"causes"| DIABETES
Cardiovascular["Cardiovascular"]
cardiomyopathy -->|"interacts with"| Cardiovascular
atherosclerosis["atherosclerosis"]
cardiomyopathy -->|"interacts with"| atherosclerosis
Heart_Failure["Heart Failure"]
cardiomyopathy -->|"interacts with"| Heart_Failure| Target | Relation | Type | Str |
|---|---|---|---|
| UQCRFS1 | interacts_with | gene | 0.50 |
| BMAL1 | activates | protein | 0.50 |
| BCL2 | activates | gene | 0.50 |
| ACSL4 | inhibits | gene | 0.50 |
| ferroptosis | inhibits | phenotype | 0.50 |
| ferroptosis | associated_with | phenotype | 0.50 |
| cancer | activates | disease | 0.50 |
| ferroptosis | activates | phenotype | 0.50 |
| LMNA | activates | gene | 0.50 |
| LMNA | interacts_with | gene | 0.50 |
| PERK | activates | gene | 0.50 |
| VEGF | activates | gene | 0.50 |
| PARKIN | activates | gene | 0.50 |
| PINK1 | activates | gene | 0.50 |
| LMNA | causes | gene | 0.50 |
| MIRO1 | activates | protein | 0.50 |
| TRKB | inhibits | gene | 0.50 |
| FIBROBLASTS | associated_with | concept | 0.50 |
| mTOR | inhibits | entity | 0.50 |
| AMPK | inhibits | protein | 0.50 |
| Microrna | inhibits | pathway | 0.50 |
| MTOR SIGNALING | inhibits | concept | 0.50 |
| CELL DEATH | associated_with | concept | 0.50 |
| Cardiac | activates | disease | 0.50 |
| disease | activates | disease | 0.50 |
| Myocardial Infarction | activates | disease | 0.50 |
| Chronic Kidney Disease | activates | disease | 0.50 |
| Retinopathy | activates | disease | 0.50 |
| PDGF | activates | concept | 0.50 |
| Cardiac | interacts_with | disease | 0.50 |
| disease | associated_with | disease | 0.50 |
| DIABETES | causes | disease | 0.50 |
| Cardiovascular | interacts_with | disease | 0.50 |
| atherosclerosis | interacts_with | disease | 0.50 |
| Heart Failure | interacts_with | disease | 0.50 |
| Macrophage | interacts_with | cell_type | 0.50 |
| disease | interacts_with | disease | 0.50 |
| MACROPHAGES | interacts_with | concept | 0.50 |
| CARDIOVASCULAR DISEASE | interacts_with | concept | 0.50 |
| inflammation | regulates | pathway | 0.50 |
| aging | regulates | phenotype | 0.50 |
| Cardiovascular | regulates | disease | 0.50 |
| FIBROSIS | regulates | disease | 0.50 |
| atherosclerosis | regulates | disease | 0.50 |
| Cardiac | regulates | disease | 0.50 |
| Macrophage | regulates | cell_type | 0.50 |
| disease | regulates | disease | 0.50 |
| MACROPHAGES | regulates | concept | 0.50 |
| Myocardial Infarction | regulates | disease | 0.50 |
| CARDIOVASCULAR DISEASE | regulates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Methamphetamine | causes | drug | 0.90 |
| UQCRFS1 | associated_with | gene | 0.65 |
| CKB | inhibits | gene | 0.65 |
| BMAL1 | activates | gene | 0.65 |
| APOPTOSIS | inhibits | gene | 0.65 |
| BCL2 | activates | gene | 0.65 |
| GPX4 | inhibits | gene | 0.65 |
| FERROPTOSIS | inhibits | gene | 0.65 |
| ACSL4 | inhibits | gene | 0.65 |
| AUTOPHAGY | inhibits | gene | 0.65 |
| ROS | inhibits | gene | 0.65 |
| PRKAA1 | inhibits | gene | 0.65 |
| VEGF | associated_with | gene | 0.65 |
| AKT | associated_with | gene | 0.65 |
| NRF2 | associated_with | gene | 0.65 |
| BAX | associated_with | gene | 0.65 |
| FIS1 | associated_with | gene | 0.65 |
| HO-1 | associated_with | gene | 0.65 |
| TLR | associated_with | gene | 0.65 |
| MTOR | associated_with | gene | 0.65 |
| CREB | associated_with | gene | 0.65 |
| PI3K | associated_with | gene | 0.65 |
| APOPTOSIS | associated_with | gene | 0.65 |
| AUTOPHAGY | associated_with | gene | 0.65 |
| TAAR1 | associated_with | gene | 0.65 |
| BCL-2 | associated_with | gene | 0.65 |
| PDGF | activates | gene | 0.65 |
| LMNA | associated_with | gene | 0.65 |
| PDGFRB | associated_with | gene | 0.65 |
| GAA | therapeutic_target | gene | 0.65 |
| FXN | therapeutic_target | gene | 0.65 |
| AGING | regulates | gene | 0.65 |
| LYRM7 | associated_with | gene | 0.65 |
| FBXO7 | associated_with | gene | 0.65 |
| MRPS31 | associated_with | gene | 0.65 |
| TIMMDC1 | associated_with | gene | 0.65 |
| PGS1 | associated_with | gene | 0.65 |
| CD14 | associated_with | gene | 0.65 |
| BCS1L | associated_with | gene | 0.65 |
| ATF4 | inhibits | gene | 0.65 |
| RNA | inhibits | gene | 0.65 |
| PERK | activates | gene | 0.65 |
| AUTOPHAGY | activates | gene | 0.65 |
| VEGF-B | activates | gene | 0.65 |
| MITOPHAGY | activates | gene | 0.65 |
| CCND1 | inhibits | gene | 0.65 |
| ERK | inhibits | gene | 0.65 |
| CYP1A1 | inhibits | gene | 0.65 |
| SLC2A1 | inhibits | gene | 0.65 |
| MMP2 | inhibits | gene | 0.65 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||