gene 2,845 words KG: VAMP2 2026-03-24
kind:genesection:genesstate:published
Contents

VAMP2 Gene - Synaptobrevin-2

🧬 Gene Info
Gene SymbolVAMP2
Full NameVAMP2 - Synaptobrevin-2
AliasesPage for VAMP2 Gene, Synaptobrevin-2
Chromosome17p13.1
Protein TypeProtein
FunctionVesicle Docking: VAMP2 on vesicles pairs with syntaxin-1A on plasma membrane
Molecular Weight12.6 kDa
Amino Acids116 aa
Exons5
UniProt IDP60880
NCBI Gene IDSearch NCBI
GeneCardsVAMP2
Human Protein AtlasVAMP2
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsNEURODEGENERATION, ALPHA-SYNUCLEIN, SNARE, SNAP-25, SYNTAXIN-1, PARKINSON
KG Connections55 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (17)

CYP46A1 Overexpression Gene Therapy
Score: 0.63
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.54
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.53

Related Analyses (7)

What is the therapeutic window between tau propagation inhib
neurodegeneration · failed
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Synaptic Vesicle Trafficking Dysfunction Validation in Parki
clinical · proposed · Score: 0.40

See Also (14)

Tau Consortium
organization · KG edge: co_discussed
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: interacts_with
NLRP3 Inflammasome Hypothesis in Parkinson's Disease
hypothesis · KG edge: expressed_in
APOE contributes to Alzheimer's disease by regulating b
hypothesis · KG edge: interacts_with

Knowledge Graph (12 edges)

VAMP2 expressed_in PSD95
VAMP2 expressed_in BAX
VAMP2 expressed_in SNAP25
VAMP2 expressed_in GAP43
VAMP2 expressed_in TRKB
VAMP2 regulates VGF
VAMP2 regulates Dementia
VAMP2 regulates Parkinson
VAMP2 interacts_with Complement
VAMP2 interacts_with NEURODEGENERATION