| Gene Symbol | VDR |
| Full Name | Vitamin D Receptor |
| Protein Type | Receptor |
| Function | encodes a nuclear receptor protein that mediates the biological effects of the active form of vitamin D (1,25-dihydroxyvitamin D3, calcitriol). |
| Primary Expression | dopaminergic neurons of the substantia nigra, where it promotes survival and function |
| Amino Acids | 427 aa |
| Pathways | MAPK, PI3K, NF-κB |
| Ensembl ID | ENSG00000111424 |
| GeneCards | VDR |
| Human Protein Atlas | VDR |
| Anti-apoptotic effects | Upregulation of Bcl-2, downregulation of pro-apoptotic proteins |
| Oxidative stress reduction | Enhancement of antioxidant enzyme expression (e.g., glutathione peroxidase, superoxide dismutase) |
| Calcium homeostasis | Modulation of calcium-binding proteins and channels |
| Mitochondrial function | Promotion of mitochondrial biogenesis and integrity |
| NGF (Nerve Growth Factor) | Regulation of neuronal survival and differentiation |
| Associated Diseases | Inflammation, Neuroinflammation, Stroke |
| Known Drugs/Compounds | paricalcitol, VITAMIN_D |
| Interactions | NFE2L2, GPX4, BMAL1, EGFR, NRF2, SLC7A11 |
| KG Connections | 200 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |