| Gene Symbol | HFE |
| Aliases | Page for HFE Protein |
| Chromosome | 6p22.2 |
| Function | The HFE gene encodes a 348-amino acid transmembrane protein that is structurally related to major histocompatibility complex (MHC) class I proteins |
| Primary Expression | various brain regions including cortex, hippocampus, basal ganglia |
| Molecular Weight | 40 kDa |
| Amino Acids | 348 aa |
| Pathways | Endocytosis |
| Ensembl ID | ENSG00000070010 |
| GeneCards | HFE |
| Human Protein Atlas | HFE |
| Iron sensing | HFE protein forms a complex with beta-2-microglobulin and interacts with transferrin receptor 1 (TfR1), modulating cellular iron uptake. |
| Regulation of hepcidin | HFE regulates the expression of hepcidin, the key hormone controlling systemic iron homeostasis. |
| Intestinal iron absorption | By modulating hepcidin, HFE controls iron absorption in the duodenum. |
| Cellular iron metabolism | Influences intracellular iron levels through transferrin-mediated iron uptake. |
| Associated Diseases | Als |
| Interactions | CAT, GSK3, TFR1 |
| KG Connections | 41 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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