gene

TFR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TFR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

551Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

TFR1 is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with ALS, Aging, Als. Connected to 277 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	TFR1
Full Name	Transferrin Receptor 1
Chromosome	3q29
Protein Type	Receptor
Target Class	Receptor
Function	Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake
Mechanism of Action	Monoclonal antibodies targeting receptor or iron chelation affecting iron uptake
Primary Expression	Ubiquitous, highest in proliferating cells and erythroid precursors
Druggability	Low (0.44)
Clinical Stage	Approved
Pathways	Amyloid, Complement, Endocytosis, Oxidative Stress, Phagocytosis
UniProt ID	P02786
NCBI Gene ID	7037
Ensembl ID	ENSG00000149571
GeneCards	TFR1
Human Protein Atlas	TFR1
Associated Diseases	ALS, Alzheimer, CANCER, Dementia, Ischemia
Known Drugs/Compounds	iron-transferrin complex, paricalcitol, valproic acid
Interactions	LRP1, CAV1, ABCB1, GBA1, LC3, FTH1
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Magnetosonic-Triggered Transferrin Receptor Cluste
KG Connections	538 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TFR1 — AlphaFold P02786 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TFR1["TFR1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    TFR1["TFR1"] -->|"interacts"| LRP1["LRP1"]
    TFR1["TFR1"] -->|"interacts"| CAV1["CAV1"]
    TFR1["TFR1"] -->|"interacts"| ABCB1["ABCB1"]
    TFR1["TFR1"] -->|"co discussed"| AQP4["AQP4"]
    TFR1["TFR1"] -->|"co discussed"| CAV1_1["CAV1"]
    LRP1_2["LRP1"] -->|"interacts"| TFR1["TFR1"]
    CAV1_3["CAV1"] -->|"interacts"| TFR1["TFR1"]
    ABCB1_4["ABCB1"] -->|"interacts"| TFR1["TFR1"]
    LRP1_5["LRP1"] -->|"co discussed"| TFR1["TFR1"]
    style TFR1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (348)

Target	Relation	Type	Str
iron uptake	mediates	process	0.95
iron-transferrin complex	binds	compound	0.95
Ferroptosis	activates	pathway	0.90
Ferroptosis	involved_in	process	0.88
tumorigenesis	involved_in	process	0.85
cancer progression	promotes	process	0.85
Ferroptosis	mediates	process	0.85
transferrin_receptor	encodes	protein	0.80
Parkinson	activates	disease	0.75
Tumor	therapeutic_target	disease	0.75
Neurodegeneration	activates	disease	0.75
Aging	activates	disease	0.75
Autophagy	activates	pathway	0.70
Ferroptosis	biomarker_for	pathway	0.70
Alzheimer's Disease	involved_in	disease	0.70
Ischemia	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Cancer	biomarker_for	disease	0.65
Lymphoma	biomarker_for	disease	0.65
Tumor	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Aging	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Dementia	contributes_to	disease	0.65
Als	contributes_to	disease	0.65
Ischemia	contributes_to	disease	0.65
Alzheimer	contributes_to	disease	0.65
Ms	contributes_to	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiac	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
Senescence	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Depression	inhibits	disease	0.65
Amyotrophic Lateral Sclerosis	activates	disease	0.65
Tumor	activates	disease	0.65
Synucleinopathy	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Dementia	associated_with	disease	0.65
Ischemia	associated_with	disease	0.65
Osteoporosis	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65

Incoming (203)

Source	Relation	Type	Str
GPX4	co_mentioned_with	gene	0.90
h-84808267	targets_gene	hypothesis	0.90
h-aa2d317c	targets_gene	hypothesis	0.90
FERROPTOSIS	activates	gene	0.90
h-84808267	targets	hypothesis	0.80
h-aa2d317c	targets	hypothesis	0.80
GPX4	activates	gene	0.80
SLC7A11	activates	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
LRP1	interacts_with	gene	0.65
CAV1	interacts_with	gene	0.65
ABCB1	interacts_with	gene	0.65
ACSL4	co_mentioned_with	gene	0.60
SLC7A11	co_mentioned_with	gene	0.60
JUN	regulates	gene	0.60
JUN	interacts_with	gene	0.60
JUN	therapeutic_target	gene	0.60
PINK1	therapeutic_target	gene	0.60
PTEN	therapeutic_target	gene	0.60
KEAP1	associated_with	gene	0.60
HFE	regulates	gene	0.60
DMT1	associated_with	gene	0.60
GPX4	contributes_to	gene	0.60
ACSL4	expressed_in	gene	0.60
GPX4	associated_with	gene	0.60
GBA1	activates	gene	0.60
CD44	activates	gene	0.60
LOX	inhibits	gene	0.60
ACSL4	inhibits	gene	0.60
XPC	regulates	gene	0.60
SRC	therapeutic_target	gene	0.60
GOT1	activates	gene	0.60
ACSL4	activates	gene	0.60
CAT	associated_with	gene	0.60
FERROPORTIN	transports	gene	0.60
TFRC	expressed_in	gene	0.60
LC3	activates	gene	0.60
IREB2	activates	gene	0.60
TP53	activates	gene	0.60
ALOX12	activates	gene	0.60
BECN1	activates	gene	0.60
SLC7A11	expressed_in	gene	0.60
FTH1	expressed_in	gene	0.60
GPX4	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
APP	treats	gene	0.60
FTL	expressed_in	gene	0.60
FSP1	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
BECLIN1	inhibits	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Magnetosonic-Triggered Transferrin Receptor Clustering	0.470	neurodegeneration	Blood-brain barrier transport mechanisms

Mentioning Analyses (1)

Scientific analyses that reference this entity

Blood-brain barrier transport mechanisms for antibody therapeutics

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.566

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446]	Sehlin D, Hultqvist G, Michno W, Aguilar	J Prev Alzheimers Dis	2025	1
Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116]	Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z	Exp Neurol	2023	1
On Iron Metabolism and Its Regulation. [PMID:33925597]	Vogt AS, Arsiwala T, Mohsen M, Vogel M,	Int J Mol Sci	2021	1
Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546]	Feng H, Schorpp K, Jin J, Yozwiak CE, Ho	Cell Rep	2020	1
Transferrin and transferrin receptors update. [PMID:29969719]	Kawabata H	Free Radic Biol Med	2019	1
A proimmunotoxin nanodrug targeting AIDS-associated non-Hodgkin lymphoma. [PMID:41592623]	Chen S, Qi T, Peng H, Kimura E, Zhang X	J Control Release	2026	0
Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877]	Lu Y, Zhang Y, Niu C	Comp Biochem Physiol A Mol Int	2026	0
Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660]	Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam	J Trace Elem Med Biol	2026	0
Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665]	Piotrowsky A, Leischner C, Schmieder H,	Oncol Rep	2026	0
Brain and Liver Dual-Targeting Oridonin Nanoparticles to Enhance Aβ Clearance fo [PMID:41944296]	Gong W, Hui W, Qiao S, Ji Q, Liu M et al	Adv Sci (Weinh)	2026	0
Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in [PMID:41947413]	Palsa K, Sahu AP, Rye DB, Trotti LM, Elc	Ann Neurol	2026	0
Pulmonary neuroendocrine cell-derived exosomes regulate iron homeostasis and oxi [PMID:41950316]	Thakur A, Zhang K, Chen J, Mei S, Chen J	Sci Adv	2026	0
O-GlcNAc Modification Orchestrates HUWE1-Mediated Ubiquitination of TfR1 to Regu [PMID:41962599]	Zhang H, Li M, Zhang J, Sun Q, Jin X et	Free Radic Biol Med	2026	0
Protective Role of Polydatin Against Vancomycin-Induced Lung Toxicity via Oxidat [PMID:41963266]	Aygörmez S, Küçükler S, Çomaklı S, Şimşe	J Appl Toxicol	2026	0
Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900]	Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng	American journal of translatio	2026	0
Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418]	Zemmouche M, Falque G, Cadet F, Gardebie	Journal of molecular graphics	2026	0
[Effects of acupuncture on ferroptosis and ferritinophagy in cerebral ischemia-r [PMID:41839581]	Wang YF, Dong YS	Zhen ci yan jiu = Acupuncture	2026	0
The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibit [PMID:41854751]	Nan K, Zhang L, Zhao Y, Yin S, Peng Y, H	Apoptosis : an international j	2026	0
The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A [PMID:41833023]	Osmanlioglu Dag SR, Tatli Cankaya II, Oz	Anti-cancer agents in medicina	2026	0
Raccoon eyes. [PMID:35789012]	Ning J	Journal of paediatrics and chi	2023	0

TFR1

Understanding Entity Pages

Summary

Wiki Pages (21)

TFR1 Gene

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Blood-Brain Barrier Dysfunction in Neurodegeneration

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

Ferroptosis in Alzheimer's Disease

metal-ion-synuclein-mitochondria-axis-parkinsons

Exosome and Extracellular Vesicle Brain Delivery

Metal Homeostasis Dysfunction Comparison Across Neurodegenerative Diseases

Ferroptosis in Neurodegeneration

iron-calcium-glymphatic-convergence-alzheimers

Blood-Brain Barrier Breakdown in Neurodegeneration

glp1-receptor-agonists

blood-brain-barrier-endothelial-cells

Receptor-Mediated Transcytosis (RMT)

Exosome-Based Drug Delivery for CBS/PSP

Iron Homeostasis Dysregulation in Neurodegeneration

Ferroptotic Neurons

Blood-Based Biomarkers for Neurodegeneration