| Gene Symbol | HFE |
| Aliases | Page for HFE Protein |
| Chromosome | 6p22.2 |
| Function | The HFE gene encodes a 348-amino acid transmembrane protein that is structurally related to major histocompatibility complex (MHC) class I proteins |
| Primary Expression | various brain regions including cortex, hippocampus, basal ganglia |
| Molecular Weight | 40 kDa |
| Amino Acids | 348 aa |
| Pathways | Endocytosis |
| Ensembl ID | ENSG00000070010 |
| GeneCards | HFE |
| Human Protein Atlas | HFE |
| Molecular weight | ~40 kDa |
| Structure | MHC class I-like fold with alpha-1, alpha-2, alpha-3 domains |
| Transmembrane domain | Single pass at C-terminus |
| Binding | Binds beta-2-microglobulin; interacts with TfR1 |
| Associated Diseases | ALS |
| Interactions | AND, CAT, TFR1, GSK3 |
| KG Connections | 42 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |