concept

GSK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

625Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	GSK3
Summary	Companies developing GSK3 inhibitors for Parkinson's disease - lithium, tideglusib, selective inhibitors, and clinical candidates targeting tau and alpha-synuclein pathology
Key Genes/Proteins	AKT, MTOR, MAPK, ERK, CDK5
Related Diseases	ALZHEIMER'S DISEASE, neurodegeneration
Related Pathways	Wnt signaling, Pi3K/Akt Pathway, PI3K/AKT, MAPK signaling, oxidative stress response

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GSK3["GSK3"]
    style GSK3 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    GSK3 -->|"interacts"| MTOR([MTOR])
    GSK3 -->|"target for"| Neuroinflammation["Neuroinflammation"]
    GSK3 -->|"contributes to"| Huntington["Huntington"]
    GSK3 -->|"target for"| Ataxia["Ataxia"]
    GSK3 -->|"target for"| Inflammation["Inflammation"]
    GSK3 -->|"target for"| Parkinson["Parkinson"]
    GSK3 -->|"target for"| Ms["Ms"]
    GSK3 -->|"target for"| Als["Als"]
    GSK3 -->|"activates"| Cancer["Cancer"]
    AKT([AKT]) -->|"phosphorylates"| GSK3
    PARKINSON([PARKINSON]) -->|"target for"| GSK3
    HIF_1_(["HIF-1Alpha"]) -->|"activates"| GSK3
    MTORC1([MTORC1]) -->|"activates"| GSK3
    CANCER([CANCER]) -->|"activates"| GSK3
    MYC([MYC]) -->|"activates"| GSK3
    MTOR -->|"activates"| GSK3
    PI3K([PI3K]) -->|"activates"| GSK3
    AMPK([AMPK]) -->|"activates"| GSK3

Outgoing (392)

Target	Relation	Type	Str
Wnt signaling	participates_in	pathway	0.90
MAPK signaling	participates_in	pathway	0.80
oxidative stress response	participates_in	pathway	0.80
MTOR	interacts_with	protein	0.70
autophagy pathway	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
neurodegeneration	implicated_in	disease	0.70
MAPK	implicated_in	gene	0.70
Neuroinflammation	therapeutic_target	disease	0.65
Huntington	contributes_to	disease	0.65
Alzheimer	associated_with	disease	0.65
Ataxia	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
ALS	activates	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Tauopathy	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Aging	expressed_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Aging	inhibits	disease	0.65
Als	inhibits	disease	0.65
Als	phosphorylates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Alzheimer	phosphorylates	disease	0.65
Tauopathy	activates	disease	0.65
Dementia	associated_with	disease	0.65
Aging	methylates	disease	0.65
Als	methylates	disease	0.65
Diabetes	inhibits	disease	0.65
Senescence	activates	disease	0.65
Fibrosis	activates	disease	0.65

Incoming (233)

Source	Relation	Type	Str
AKT	phosphorylates	protein	0.85
Pi3K/Akt Pathway	regulates	pathway	0.85
PI3K/AKT	regulates	pathway	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.82
ERK	activates	gene	0.70
CDK5	activates	gene	0.70
CDK5	implicated_in	gene	0.70
AMYLOID	regulates	protein	0.66
TAU	regulates	protein	0.66
PARKINSON	therapeutic_target	gene	0.60
HIF-1Α	activates	gene	0.60
MTORC1	activates	gene	0.60
CANCER	activates	gene	0.60
MYC	activates	gene	0.60
GLUT1	activates	gene	0.60
HK2	activates	gene	0.60
LC3	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
STX17	associated_with	gene	0.60
ACAT1	associated_with	gene	0.60
OPTINEURIN	associated_with	gene	0.60
RB1	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
ACETYL-COA	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
P53	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
SQSTM1	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
AGING	expressed_in	gene	0.60
DEMENTIA	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
PRESENILIN	expressed_in	gene	0.60
GENES	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
WIF1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GSK3

Understanding Entity Pages

Wiki Pages (21)

PD GSK3 Inhibitor Companies

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

CBS/PSP Rehabilitation Master Guide

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

Therapeutics

CBS/PSP Treatment Rankings

GSK-3β in Neurodegeneration

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

omega-3-fatty-acids-neurodegeneration

Vascular Cognitive Impairment (VCI)

Lithium for PSP/CBS — Phase 2 Trial

nf1-protein

deferiprone-neurodegeneration

lithium-tauopathy

cognitive-reserve-cbs-psp

Excitotoxicity in Neurodegeneration

vitamin-d-therapy-neurodegeneration