concept

GSK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

616Connections

3Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	GSK3
Key Genes/Proteins	ABL1, ACAT1, ACETYL-COA, Actin, AGING, AIF
Related Diseases	Aging, Als, ALS, Alzheimer, Alzheimer's disease
Related Pathways	Akt
Linked Hypotheses	3 hypotheses

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GSK3["GSK3"]
    style GSK3 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    GSK3 -->|"interacts"| MTOR([MTOR])
    GSK3 -->|"target for"| Neuroinflammation["Neuroinflammation"]
    GSK3 -->|"contributes to"| Huntington["Huntington"]
    GSK3 -->|"target for"| Ataxia["Ataxia"]
    GSK3 -->|"target for"| Inflammation["Inflammation"]
    GSK3 -->|"target for"| Parkinson["Parkinson"]
    GSK3 -->|"target for"| Ms["Ms"]
    GSK3 -->|"target for"| Als["Als"]
    GSK3 -->|"activates"| Cancer["Cancer"]
    AKT([AKT]) -->|"phosphorylates"| GSK3
    PARKINSON([PARKINSON]) -->|"target for"| GSK3
    HIF_1_(["HIF-1Alpha"]) -->|"activates"| GSK3
    MTORC1([MTORC1]) -->|"activates"| GSK3
    CANCER([CANCER]) -->|"activates"| GSK3
    MYC([MYC]) -->|"activates"| GSK3
    MTOR -->|"activates"| GSK3
    PI3K([PI3K]) -->|"activates"| GSK3
    AMPK([AMPK]) -->|"activates"| GSK3

Outgoing (386)

Target	Relation	Type	Str
Wnt signaling	participates_in	pathway	0.90
oxidative stress response	participates_in	pathway	0.80
MAPK signaling	participates_in	pathway	0.80
MTOR	interacts_with	protein	0.70
neurodegeneration	implicated_in	disease	0.70
autophagy pathway	participates_in	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
MAPK	implicated_in	gene	0.70
Tauopathy	expressed_in	disease	0.65
Ataxia	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Aging	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Senescence	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Dementia	expressed_in	disease	0.65
Fibrosis	activates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Huntington	contributes_to	disease	0.65
Alzheimer	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Diabetes	inhibits	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Als	phosphorylates	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Aging	activates	disease	0.65
Als	regulates	disease	0.65
Neurodegeneration	activates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Aging	methylates	disease	0.65
Als	methylates	disease	0.65
Als	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Dementia	associated_with	disease	0.65
Cancer	activates	disease	0.65
ALS	activates	disease	0.65
Aging	inhibits	disease	0.65
Tumor	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Alzheimer	activates	disease	0.65
Tauopathy	activates	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	phosphorylates	disease	0.65

Incoming (230)

Source	Relation	Type	Str
AKT	phosphorylates	protein	0.85
PI3K/AKT	regulates	pathway	0.85
Pi3K/Akt Pathway	regulates	pathway	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.82
ERK	activates	gene	0.70
CDK5	associated_with	gene	0.70
CDK5	activates	gene	0.70
AMYLOID	regulates	protein	0.66
TAU	regulates	protein	0.66
ERK1	associated_with	gene	0.60
EPHA8	associated_with	gene	0.60
P38	associated_with	gene	0.60
GAIN	regulates	gene	0.60
CBP	activates	gene	0.60
SIRT1	associated_with	gene	0.60
GENES	inhibits	gene	0.60
AMYLOID	inhibits	gene	0.60
WIF1	associated_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
WNT	associated_with	gene	0.60
GMPR	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
DAP12	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
LRRN1	regulates	gene	0.60
NEURON	regulates	gene	0.60
SMPD1	regulates	gene	0.60
PKC	associated_with	gene	0.60
DEMENTIA	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
PRESENILIN	expressed_in	gene	0.60
ATG	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
CREB	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
AMPK	therapeutic_target	gene	0.60
NPTX2	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
GMPR	therapeutic_target	gene	0.60
TAU	therapeutic_target	gene	0.60
MET	associated_with	gene	0.60
SYK	activates	gene	0.60
SREBP2	inhibits	gene	0.60
AGING	inhibits	gene	0.60
CDK5	therapeutic_target	gene	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
MAP6-CRMPS cooperative phosphorylation by GSK3β	0.700	neurodegeneration	-
GSK3β Inhibition to Prevent α-Synuclein Phosphorylation and	0.429	neurodegeneration	Does RGS6 upregulation or D2 autorecepto
GSK3β-Dependent Tau Phosphorylation Cycling Modulation	0.000	-	Tau propagation mechanisms and therapeut

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GSK3 in their description or question text

No additional research found

GSK3

Understanding Entity Pages

Wiki Pages (15)

GSK3 Signaling in Parkinson's Disease

GSK3B Gene - Glycogen Synthase Kinase 3 Beta

GSK3-beta Protein

GSK3B (Glycogen Synthase Kinase 3 Beta)

GSK3-beta Signaling Pathway

GSK3B Protein (Glycogen Synthase Kinase 3 Beta)

GSK3beta-Tau Phosphorylation Complex

GSK3 Beta in Neurodegeneration

GSK3 Inhibitor Therapy

GSK3B — Glycogen Synthase Kinase 3 Beta

GSK3A Protein

GSK3A Gene

GSK3B Protein** is a protein. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target. Redirecting to [GSK3B Protein (Glycogen Synthase Kinase 3 Beta)

GSK3β (Glycogen Synthase Kinase 3 Beta) Neurons

PD GSK3 Inhibitor Companies