Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HYPERGLYCEMIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
graph TD
HYPERGLYCEMIA["HYPERGLYCEMIA"]
HYPERGLYCEMIA -->|"promotes"| Reactive_Oxygen_Species["Reactive Oxygen Species"]
HYPERGLYCEMIA -->|"causes"| Neurodegeneration["Neurodegeneration"]
HYPERGLYCEMIA -->|"downregulates"| SQSTM1["SQSTM1"]
HYPERGLYCEMIA -->|"downregulates"| YTHDC1["YTHDC1"]
HYPERGLYCEMIA -->|"causes"| oxidative_stress["oxidative stress"]
HYPERGLYCEMIA -->|"contributes to"| Sarcopenia["Sarcopenia"]
HYPERGLYCEMIA -->|"contributes to"| Cognitive_Decline["Cognitive Decline"]
Metformin["Metformin"] -->|"treats"| HYPERGLYCEMIA
PAQR4["PAQR4"] -->|"causes"| HYPERGLYCEMIA
Leptin["Leptin"] -->|"treats"| HYPERGLYCEMIA
CRH_NEURONS["CRH_NEURONS"] -->|"regulates"| HYPERGLYCEMIA
HSL_AXIS["HSL_AXIS"] -->|"regulates"| HYPERGLYCEMIA
ADRENAL["ADRENAL"] -->|"regulates"| HYPERGLYCEMIA| Target | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGY | activates | pathway | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CRH_NEURONS | regulates | cell_type | 0.72 |
| HSL_AXIS | regulates | pathway | 0.72 |
| ADRENAL | regulates | organ | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||