concept

TYPE 2 DIABETES MELLITUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TYPE 2 DIABETES MELLITUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

28Outgoing

35Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	TYPE 2 DIABETES MELLITUS

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    TYPE_2_DIABETES_MELLITUS["TYPE 2 DIABETES MELLITUS"]
    TYPE_2_DIABETES_MELLITUS -->|"causes"| Insulin_Resistance["Insulin Resistance"]
    TYPE_2_DIABETES_MELLITUS -->|"causes"| Neuroinflammation["Neuroinflammation"]
    TYPE_2_DIABETES_MELLITUS -->|"causes"| Neurodegeneration["Neurodegeneration"]
    TYPE_2_DIABETES_MELLITUS -->|"causes"| Diabetic_Retinopathy["Diabetic Retinopathy"]
    TYPE_2_DIABETES_MELLITUS -->|"causes"| Peripheral_Neuropathy["Peripheral Neuropathy"]
    TYPE_2_DIABETES_MELLITUS -->|"causes"| Sarcopenia["Sarcopenia"]
    TYPE_2_DIABETES_MELLITUS -->|"causes"| Cognitive_Decline["Cognitive Decline"]
    GLP_1R_Agonists["GLP-1R Agonists"] -->|"treats"| TYPE_2_DIABETES_MELLITUS
    miR_130a["miR-130a"] -.biomarker for.-> TYPE_2_DIABETES_MELLITUS
    MMP9["MMP9"] -.biomarker for.-> TYPE_2_DIABETES_MELLITUS
    TPM2["TPM2"] -->|"upregulates"| TYPE_2_DIABETES_MELLITUS
    quercetin["quercetin"] -->|"treats"| TYPE_2_DIABETES_MELLITUS
    metformin["metformin"] -->|"treats"| TYPE_2_DIABETES_MELLITUS
    mtDNA_mutations["mtDNA mutations"] -->|"causes"| TYPE_2_DIABETES_MELLITUS
    semaglutide["semaglutide"] -->|"treats"| TYPE_2_DIABETES_MELLITUS

Outgoing (28)

Target	Relation	Type	Str
Diabetic Retinopathy	causes	disease	0.95
Peripheral Neuropathy	causes	disease	0.95
Peripheral Neuropathy	risk_factor_for	disease	0.95
Insulin Resistance	causes	phenotype	0.95
Neuroinflammation	causes	process	0.95
Neurodegeneration	causes	process	0.95
Sarcopenia	causes	phenotype	0.95
Insulin Resistance	associated_with	phenotype	0.95
Alzheimer'S Disease	associated_with	disease	0.95
Sarcopenia	associated_with	phenotype	0.95
Cognitive Decline	causes	phenotype	0.92
ALZHEIMER'S DISEASE	associated_with	disease	0.92
PARKINSON'S DISEASE	associated_with	disease	0.92
Neurodegenerative Disease Risk	associated_with	phenotype	0.90
Schwann Cells	associated_with	cell_type	0.90
Alzheimer's Disease	associated_with	disease	0.90
Alzheimer's Disease	risk_factor_for	disease	0.90
Parkinson's Disease	risk_factor_for	disease	0.90
Diabetic Nephropathy	causes	disease	0.88
Accelerated Aging	associated_with	phenotype	0.85
Neurodegeneration	contributes_to	process	0.85
Neurodegeneration	associated_with	process	0.85
Neuroinflammation	associated_with	process	0.85
Cognitive Decline	associated_with	phenotype	0.85
Mitochondrial Dysfunction	associated_with	process	0.75
Parkinson's Disease	associated_with	disease	0.75
cognitive impairment	causes	disease	0.70
Alzheimer's disease	associated_with	disease	0.70

Incoming (35)

Source	Relation	Type	Str
GLP-1R Agonists	treats	drug	0.95
SDHHQ	treats	drug	0.95
Insulin Resistance	associated_with	phenotype	0.95
Glp-1 Receptor Agonists	treats	drug	0.95
hyperglycemia	associated_with	phenotype	0.92
Glp1R Agonists	treats	drug	0.90
plasma proteins	biomarker_for	protein	0.90
CLOCK	implicated_in	gene	0.90
Parkinson's Disease	associated_with	disease	0.90
MIR130A	biomarker_for	gene	0.88
miR-130a	biomarker_for	biomarker	0.85
CLOCK	associated_with	gene	0.85
Kaempferol	contributes_to	compound	0.85
circadian rhythm disruption	risk_factor_for	process	0.85
plasma proteins	risk_factor_for	protein	0.85
Quercetin	contributes_to	compound	0.85
TGFB1	biomarker_for	protein	0.82
MMP9	biomarker_for	gene	0.80
TCF7L2	associated_with	gene	0.80
PINK1	associated_with	gene	0.80
cellular senescence	contributes_to	process	0.80
plasma proteome	mediates	protein	0.80
TPM2	upregulates	gene	0.75
Astragalus Propinqu	treats	drug	0.75
P2RX7	associated_with	gene	0.75
Parkinson'S Disease	associated_with	disease	0.75
quercetin	treats	drug	0.70
TNF	associated_with	protein	0.70
BMAL1	associated_with	gene	0.70
mtDNA mutations	causes	process	0.70
mtDNA heteroplasmy	associated_with	process	0.70
semaglutide	treats	drug	0.70
MAPK	associated_with	protein	0.70
metformin	treats	drug	0.70
CLU	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TYPE 2 DIABETES MELLITUS

Understanding Entity Pages

Wiki Pages (20)

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Synaptic Failure in Neurodegeneration

Metabolic Dysfunction in Alzheimer's Disease

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Parkinson's Disease Metabolism

Vascular Risk Factors in Alzheimer's Disease

Taisho Pharmaceutical

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Metabolic Dysfunction in 4R-Tauopathies

MDS 2026: Neuroprotection and Neurorestorative Strategies for Parkinson's Disease

sglt2-inhibitors-neurodegeneration

Iron Dysregulation in Neurodegeneration

Myotonic Dystrophy

nct05266417-nose-pd

SLC2A4RG Protein (SLC2A4 Regulator)

DPP-4 Inhibitor Therapy (Gliptins)