| Gene Symbol | ent-gene-d18a9f38 |
| NAD+ depletion | PARP1 consumes NAD+ during hyperactivation, depleting cellular energy reserves and triggering AIF-mediated cell death.[@nad2020] |
| Clinical momentum | PARP1 inhibitors (olaparib, niraparib, rucaparib) are approved for oncology; repurposing for neurodegeneration is feasible.[@parp2019a] |
| Combination potential | PARP1 inhibition synergizes with NAD+ precursors, SIRT1 activators, and mitochondrial protectants.[@synergistic2020] |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |