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mechanism 2,987 words KG: dopamine 2026-04-01
kind:mechanismsection:mechanismsstate:publishedevidence:strong
Contents

Dopamine Transporter (DAT) Dysfunction Pathway in Parkinson's Disease

⚙ Mechanism Info
NameDopamine Transporter (DAT) Dysfunction Pathway in Parkinson's Disease
SummarySLC6A3 gene, dopamine reuptake, DAT imaging, DaTscan, PD biomarkers
Key Genes/ProteinsCOMT, NRF2, GPX4, BDNF
Related Diseasesdiabetic retinal neurodegeneration
Linked Hypotheses6 hypotheses

Knowledge Graph

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Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
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validation · proposed · Score: 0.40

See Also (3)

Alzheimer Indonesia
institution · KG edge: activatesAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesacetylcholine
general · KG edge: co_discussed

Knowledge Graph (12 edges)

dopamine regulates neuronal uptake
dopamine treats diabetic retinal neurodegeneration
dopamine activates NRF2
dopamine regulates GPX4
dopamine regulates BDNF
dopamine expressed_in striatum
dopamine expressed_in mesolimbic circuit
dopamine loss_affects neuron
dopamine loss_affects SNCA
dopamine loss_affects Alzheimer
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