gene

ISG15

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ISG15: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

277Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Comprehensive page for ISG15 gene encoding an ubiquitin-like protein involved in neuroinflammation and protein quality control

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🧬 Gene Info

Gene Symbol	ISG15
Full Name	Interferon-Stimulated Gene 15
Chromosome	1p36.33
Function	is a ubiquitin-like protein that is induced by type I interferons (IFN-α/β) and plays a critical role in the innate immune response.
Amino Acids	165 aa
Exons	2
Pathways	Akt, Autophagy, Lipid Metabolism, Mapk, Pi3K
UniProt ID	[P51959](https://www.uniprot.org/uniprot/P51959)
Ensembl ID	ENSG00000187608
OMIM	607117
GeneCards	ISG15
Human Protein Atlas	ISG15
Associated Diseases	Als, Alzheimer Disease, Cancer, Cognitive Deficits, Depression, Inflammation
Interactions	STAT1, CGAS, CXCL10, MAPT, IRF1, PINK1
KG Connections	277 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ISG15["ISG15"]
    ISG15 -->|"participates in"| INTERFERON_RESPONSE["INTERFERON_RESPONSE"]
    ISG15 -->|"regulates"| Als["Als"]
    ISG15 -->|"activates"| Aging["Aging"]
    ISG15 -->|"activates"| Cancer["Cancer"]
    ISG15 -->|"activates"| Alzheimer["Alzheimer"]
    ISG15 -->|"regulates"| Ataxia["Ataxia"]
    ISG15 -->|"activates"| Ms["Ms"]
    ISG15 -->|"activates"| Inflammation["Inflammation"]
    ISG15 -->|"regulates"| ALS["ALS"]
    ISG15 -->|"activates"| STAT1["STAT1"]
    CSF2["CSF2"] -->|"regulates"| ISG15
    NAMPT["NAMPT"] -->|"regulates"| ISG15
    FGF2["FGF2"] -->|"regulates"| ISG15
    CXCL10["CXCL10"] -->|"activates"| ISG15
    HSPA1A["HSPA1A"] -->|"regulates"| ISG15
    FGF8["FGF8"] -->|"regulates"| ISG15
    TLR4["TLR4"] -->|"regulates"| ISG15
    P38["P38"] -->|"regulates"| ISG15
    ERK["ERK"] -->|"regulates"| ISG15
    PI3K["PI3K"] -->|"regulates"| ISG15

Outgoing (185)

Target	Relation	Type	Str
HDAC6	inhibits	gene	0.95
Autophagosome-Lysosome Fusion	inhibits	process	0.95
Autophagy-Lysosomal Pathway	regulates	pathway	0.95
Autophagy	inhibits	process	0.95
Alzheimer Disease	implicated_in	disease	0.95
HDAC6	binds	gene	0.90
MAPT	promotes	gene	0.90
Cognitive Deficits	causes	phenotype	0.90
Synaptic Damage	mediates	phenotype	0.90
Selective Autophagy	regulates	process	0.85
Als	regulates	disease	0.75
Inflammation	activates	disease	0.75
INTERFERON_RESPONSE	participates_in	pathway	0.72
AKT	regulates	gene	0.70
Autophagy	activates	pathway	0.70
Pi3K/Akt	regulates	pathway	0.70
Encephalitis	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Aging	activates	disease	0.65
Cancer	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ataxia	regulates	disease	0.65
Ms	activates	disease	0.65
ALS	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Pancreatic Cancer	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	inhibits	disease	0.65
Als	inhibits	disease	0.65
Als	activates	disease	0.65
STAT1	activates	gene	0.60
CSF2RA	regulates	gene	0.60
S100A8	regulates	gene	0.60
STAT1	associated_with	gene	0.60
USP18	associated_with	gene	0.60
CXCL12	associated_with	gene	0.60
CGAS	activates	gene	0.60
CXCL10	activates	gene	0.60
FGF8	regulates	gene	0.60
P38	regulates	gene	0.60
NAMPT	regulates	gene	0.60
CSF2	regulates	gene	0.60
HSPA1A	regulates	gene	0.60
MAPT	activates	gene	0.60
IRF1	activates	gene	0.60
PINK1	activates	gene	0.60
MMP2	associated_with	gene	0.60

Incoming (92)

Source	Relation	Type	Str
MAPT	upregulates	gene	0.95
CSF2	regulates	gene	0.60
NAMPT	regulates	gene	0.60
FGF2	regulates	gene	0.60
CXCL10	activates	gene	0.60
HSPA1A	regulates	gene	0.60
FGF8	regulates	gene	0.60
TLR4	regulates	gene	0.60
SGK1	associated_with	gene	0.60
FKBP5	associated_with	gene	0.60
A2M	associated_with	gene	0.60
AQP4	associated_with	gene	0.60
TNF	associated_with	gene	0.60
P2RX7	associated_with	gene	0.60
P38	regulates	gene	0.60
PI3K	regulates	gene	0.60
STAT1	activates	gene	0.60
S100A8	regulates	gene	0.60
AKT	regulates	gene	0.60
STING	activates	gene	0.60
HDAC6	activates	gene	0.60
UBIQUITIN	regulates	gene	0.60
TAU	activates	gene	0.60
MFN1	activates	gene	0.60
PARKIN	activates	gene	0.60
CXCL8	associated_with	gene	0.60
IL6	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
CD8	regulates	gene	0.60
EGFR	associated_with	gene	0.60
HSP90AA1	associated_with	gene	0.60
ACTB	associated_with	gene	0.60
IFIH1	associated_with	gene	0.60
CSF2RA	regulates	gene	0.60
BECN1	activates	gene	0.60
SLC17A7	therapeutic_target	gene	0.60
GRM5	therapeutic_target	gene	0.60
SCN8A	therapeutic_target	gene	0.60
STAT1	therapeutic_target	gene	0.60
FGF13	therapeutic_target	gene	0.60
SCN2B	therapeutic_target	gene	0.60
CDK5R2	therapeutic_target	gene	0.60
IRF7	associated_with	gene	0.60
SCN2B	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
HERC5	therapeutic_target	gene	0.60
CDK5R2	interacts_with	gene	0.60
FGF13	interacts_with	gene	0.60
GRM5	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ISG15

Understanding Entity Pages

Summary

Wiki Pages (21)

ISG15 — Interferon-Stimulated Gene 15

IL28B (Interleukin 28B)

cGAS-STING Pathway Dysregulation Hypothesis in Parkinson's Disease

Interferon Signaling in Neurodegeneration

herc5

HERC6 — HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 6

FGF8 Gene

cGAS-STING Cytosolic DNA Sensing Pathway in Neurodegeneration

Spatial Multi-Omics Integration for Neurodegeneration

CSF2RA — Colony Stimulating Factor 2 Receptor Alpha Chain

Spatial Multi-Omics Integration for Neurodegeneration

FANCM Protein

SUMOylation in Neurodegeneration

Microglia CD8+ T Cell Recruitment in White Matter Degeneration

GM-CSF Receptor Alpha Chain

BRD3 (Bromodomain-Containing Protein 3)

IFIH1 Gene (MDA5)

CBS vs PSP Phenotype Determinants — Single-Nucleus Multi-Omics Study

SCN2B Gene - Sodium Channel Beta Subunit