gene

GRM5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRM5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

118Connections

1Hypotheses

1Analyses

50Outgoing

46Incoming

0Experiments

1Debates

Summary

Page for GRM5 Gene - Metabotropic Glutamate Receptor 5

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🧬 Gene Info

Gene Symbol	GRM5
Aliases	Page for GRM5 Gene
Protein Type	Receptor
Function	mGluR5 mediates modulatory glutamate signaling
Subcellular Localization	Plasma membrane, Dendritic spines
Molecular Weight	132 kDa
Exons	10
Pathways	MAPK
UniProt ID	[P41594](https://www.uniprot.org/uniprot/P41594)
GeneCards	GRM5
Human Protein Atlas	GRM5
Associated Diseases	Alzheimer, Autism, Bipolar, Cancer, Inflammation, Ms
Interactions	CACNA1B, CACNA1H, CDK5R2, DRD1, DRD2, FGF13
SciDEX Hypotheses	Metabotropic Glutamate Receptor-Based Sleep Stabil
KG Connections	118 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GRM5["GRM5"]
    Ms{"Ms"}
    GRM5 -->|"associated with"| Ms
    Schizophrenia{"Schizophrenia"}
    GRM5 -->|"associated with"| Schizophrenia
    GABARAP["GABARAP"]
    GRM5 -->|"associated with"| GABARAP
    GABRB1["GABRB1"]
    GRM5 -->|"associated with"| GABRB1
    Toll_Like_Receptor(["Toll-Like Receptor"])
    GRM5 -->|"associated with"| Toll_Like_Receptor
    neurodegeneration["neurodegeneration"]
    GRM5 -->|"implicated in"| neurodegeneration
    style GRM5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (72)

Target	Relation	Type	Str
sleep-wake cycle	regulates	phenotype	0.70
Bipolar	associated_with	disease	0.65
Encephalitis	therapeutic_target	disease	0.65
Inflammation	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Autism	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Ms	associated_with	disease	0.65
DRD1	associated_with	gene	0.60
Rb	associated_with	protein	0.60
ISG15	interacts_with	gene	0.60
SCN2B	interacts_with	gene	0.60
SCN8A	interacts_with	gene	0.60
STAT1	interacts_with	gene	0.60
ISG15	associated_with	gene	0.60
SCN2B	associated_with	gene	0.60
SCN8A	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
Interferon	therapeutic_target	protein	0.60
GABRA1	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
Cdk5	therapeutic_target	protein	0.60
Toll-Like Receptor	associated_with	pathway	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
FGF13	therapeutic_target	gene	0.60
CDK5R2	therapeutic_target	gene	0.60
SLC1A1	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
GENES	associated_with	gene	0.60
GABRB1	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60
Interferon Signaling	therapeutic_target	pathway	0.60
App	therapeutic_target	protein	0.60
Fgf	therapeutic_target	protein	0.60
GABAergic neurons	expressed_in	cell_type	0.60
SCN8A	targets	gene	0.60
STAT1	targets	gene	0.60
SCN2B	targets	gene	0.60
ISG15	targets	gene	0.60
SLC17A7	targets	gene	0.60

Incoming (46)

Source	Relation	Type	Str
CDK5R2	targets	gene	0.60
SLC1A1	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
GRIK4	associated_with	gene	0.60
GRIA1	associated_with	gene	0.60
DRD1	associated_with	gene	0.60
CACNA1B	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
FGF13	targets	gene	0.60
GABRB2	associated_with	gene	0.60
CACNA1H	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
GENES	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
SLC17A7	therapeutic_target	gene	0.60
STAT1	therapeutic_target	gene	0.60
SCN8A	therapeutic_target	gene	0.60
ISG15	therapeutic_target	gene	0.60
GRIK4	interacts_with	gene	0.60
SCN2B	therapeutic_target	gene	0.60
CDK5R2	interacts_with	gene	0.60
FGF13	interacts_with	gene	0.60
CACNA1H	interacts_with	gene	0.60
GABRB2	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
SCN2B	associated_with	gene	0.60
STAT1	associated_with	gene	0.60
ISG15	associated_with	gene	0.60
SCN8A	associated_with	gene	0.60
FGF13	associated_with	gene	0.60
SLC17A7	associated_with	gene	0.60
CDK5R2	associated_with	gene	0.60
HTR2A	associated_with	gene	0.60
ISG15	interacts_with	gene	0.50
STAT1	interacts_with	gene	0.50
SCN2B	interacts_with	gene	0.50
SCN8A	interacts_with	gene	0.50
DRD2	interacts_with	gene	0.50
HTR2C	interacts_with	gene	0.50
DRD1	interacts_with	gene	0.50
CACNA1B	interacts_with	gene	0.50
GABRA1	interacts_with	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Metabotropic Glutamate Receptor-Based Sleep Stabilization Th	0.000	-	Sleep disruption as cause and consequenc

Mentioning Analyses (1)

Scientific analyses that reference this entity

Sleep disruption as cause and consequence of neurodegeneration

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.763

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Sleep disruption as cause and consequence of neurodegeneration

closed · Rounds: 4 · Score: 0.91 · 2026-04-06

Related Research

Hypotheses and analyses mentioning GRM5 in their description or question text

No additional research found

GRM5

Understanding Entity Pages

Summary

Wiki Pages (3)

GRM5 Gene - Metabotropic Glutamate Receptor 5

GRM5 Gene

mGluR5 (GRM5) Neurons

Pathway Diagram

Outgoing (72)

Incoming (46)

Targeting Hypotheses (1)

Mentioning Analyses (1)

Sleep disruption as cause and consequence of neurodegeneration

Experiments (0)

Related Papers (0)

Debates (1)

Sleep disruption as cause and consequence of neurodegeneration

Related Research