protein

Fgf

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Fgf: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

466Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	FGF
Pathways	oxidative stress response, TGF-beta signaling, Angiogenesis, Oxidative Stress, Immune Response
GeneCards	FGF
Human Protein Atlas	FGF
Neural stem cells (NSCs)	Multipotent cells that can self-renew
Neural progenitor cells	More restricted in differentiation potential
Precursor cells	Committed to specific neuronal or glial lineages
Transcription factors	Pax6, Sox2, Nestin
Epigenetic regulators	DNA methylation, histone modifications
Non-coding RNAs	miRNAs regulating proliferation
Growth factors	EGF, FGF, BDNF
Morphogens	Shh, BMPs, Wnts
Extracellular matrix	Integrins, proteoglycans
Vascular niche	Blood-brain barrier interactions
Reduced hippocampal neurogenesis	Decreased SGZ proliferation
Associated Diseases	Als, Cancer, Epilepsy
Interactions	FGF2, VEGFB, BMP2, RUNX2, ANGPT1, PDGFRB
KG Connections	273 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Fgf["Fgf"] -->|"regulates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Fgf["Fgf"] -->|"biomarker for"| Senescence["Senescence"]
    style Senescence fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Fgf["Fgf"] -->|"biomarker for"| Aging["Aging"]
    style Aging fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Fgf["Fgf"] -->|"biomarker for"| Fibrosis["Fibrosis"]
    style Fibrosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Fgf["Fgf"] -->|"biomarker for"| Neuroinflammation["Neuroinflammation"]
    style Neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Fgf["Fgf"] -->|"biomarker for"| Neurodegeneration["Neurodegeneration"]
    style Neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Fgf["Fgf"] -->|"biomarker for"| Alzheimer["Alzheimer"]
    style Alzheimer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    FGF2["FGF2"] -->|"activates"| Fgf["Fgf"]
    style FGF2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    VEGFB["VEGFB"] -->|"activates"| Fgf["Fgf"]
    style VEGFB fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BMP2["BMP2"] -->|"activates"| Fgf["Fgf"]
    style BMP2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RUNX2["RUNX2"] -->|"activates"| Fgf["Fgf"]
    style RUNX2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    ANGPT1["ANGPT1"] -->|"activates"| Fgf["Fgf"]
    style ANGPT1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Fgf fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (201)

Target	Relation	Type	Str
Als	regulates	disease	0.60
Als	degrades	disease	0.60
Als	biomarker_for	disease	0.60
Senescence	biomarker_for	disease	0.60
Aging	biomarker_for	disease	0.60
Fibrosis	biomarker_for	disease	0.60
Neuroinflammation	biomarker_for	disease	0.60
Neurodegeneration	biomarker_for	disease	0.60
Alzheimer	biomarker_for	disease	0.60
Aging	regulates	disease	0.60
Aging	activates	disease	0.60
Diabetes	activates	disease	0.60
Als	inhibits	disease	0.60
Cancer	therapeutic_target	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Alzheimer	activates	disease	0.60
Als	associated_with	disease	0.60
Epilepsy	associated_with	disease	0.60
Als	expressed_in	disease	0.60
Cancer	regulates	disease	0.60
Cancer	associated_with	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Amyotrophic Lateral Sclerosis	transports	disease	0.60
Parkinson	transports	disease	0.60
Alzheimer	transports	disease	0.60
Obesity	contributes_to	disease	0.60
Aging	contributes_to	disease	0.60
Als	causes	disease	0.60
Epilepsy	causes	disease	0.60
Als	therapeutic_target	disease	0.60
Cancer	interacts_with	disease	0.60
Cancer	causes	disease	0.60
Cancer	inhibits	disease	0.60
Mapk	regulates	pathway	0.55
Pi3K/Akt	regulates	pathway	0.55
Epigenetic	degrades	pathway	0.55
Apoptosis	biomarker_for	pathway	0.55
Autophagy	regulates	pathway	0.55
Synaptic Plasticity	activates	pathway	0.55
Mapk	activates	pathway	0.55
Mitophagy	activates	pathway	0.55
Innate Immunity	activates	pathway	0.55
Apoptosis	inhibits	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Neurogenesis	activates	pathway	0.55
Interferon Signaling	therapeutic_target	pathway	0.55
Cholesterol	activates	pathway	0.55
Immune Response	associated_with	pathway	0.55
Nf-Κb	activates	pathway	0.55
Autophagy	inhibits	pathway	0.55

Incoming (265)

Source	Relation	Type	Str
FGF2	activates	gene	0.60
VEGFB	activates	gene	0.60
BMP2	activates	gene	0.60
RUNX2	activates	gene	0.60
ANGPT1	activates	gene	0.60
PDGFRB	activates	gene	0.60
VEGF	activates	gene	0.60
BCL-2	regulates	gene	0.60
LGALS9	regulates	gene	0.60
EPOR	regulates	gene	0.60
STAT1	regulates	gene	0.60
ISG15	regulates	gene	0.60
P38	regulates	gene	0.60
TLR4	regulates	gene	0.60
ERK	regulates	gene	0.60
CXCL10	regulates	gene	0.60
EPO	regulates	gene	0.60
CSF2	regulates	gene	0.60
MAPK	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
TFEB	activates	gene	0.60
PPAR	activates	gene	0.60
FGF21	activates	gene	0.60
ULK1	activates	gene	0.60
LC3	activates	gene	0.60
ATGL	activates	gene	0.60
ATG7	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
PLAU	activates	gene	0.60
S100B	biomarker_for	gene	0.60
GPNMB	biomarker_for	gene	0.60
CX3CL1	activates	gene	0.60
APP	biomarker_for	gene	0.60
BDNF	activates	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
VIM	activates	gene	0.60
HMGB1	biomarker_for	gene	0.60
IGF-1	biomarker_for	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
FGF23	activates	gene	0.60
IL-6	activates	gene	0.60
PGRN	activates	gene	0.60
AMYLOID	biomarker_for	gene	0.60
CXCL10	activates	gene	0.60
AGING	biomarker_for	gene	0.60
GHRL	biomarker_for	gene	0.60
VIMENTIN	activates	gene	0.60
FNDC5	activates	gene	0.60
COMPLEMENT	biomarker_for	gene	0.60
PROGRANULIN	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Fgf

Understanding Entity Pages

Wiki Pages (21)

Neural Precursor Development

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

nct07165106

Growth Factor Therapies

VEGF/Angiogenesis Pathway in Neurodegeneration

Mitochondrial Dysfunction in Neurodegeneration

Growth Factor Therapeutics: Investment Landscape Analysis

IGF-1 Signaling Pathway in Neurodegeneration

GBA1→GCase→Lysosome→PD Causal Chain

Notch Signaling Pathway in Neurodegeneration

FGF10 — Fibroblast Growth Factor 10

Neurogenesis

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

Neurogenesis and Neurodegeneration

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

Alzheimer's Disease Synaptic Repair and Neuroprotection Companies

Neurotrophic Factors in Neurodegeneration

PTCH2 Gene