concept

FGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

510Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FGF
Key Genes/Proteins	Actin, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, Amyloid
Related Diseases	Aging, ALS, Alzheimer
Related Pathways	Angiogenesis, Apoptosis, apoptosis pathway

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FGF["FGF"]
    style FGF fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    FGF -->|"regulates"| MTOR([MTOR])
    FGF -->|"regulates"| MYELINATION["MYELINATION"]
    FGF -->|"expressed in"| Cancer["Cancer"]
    FGF -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    FGF -->|"regulates"| Alzheimer["Alzheimer"]
    FGF -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    FGF -->|"regulates"| Inflammation["Inflammation"]
    DNA([DNA]) -->|"activates"| FGF
    FGF1([FGF1]) -->|"interacts"| FGF
    ERK1_2([ERK1/2]) -->|"activates"| FGF
    NEURODEGENERATION([NEURODEGENERATION]) -->|"regulates"| FGF
    EXERCISE([EXERCISE]) -->|"regulates"| FGF
    NEUROINFLAMMATION([NEUROINFLAMMATION]) -->|"regulates"| FGF
    MITOCHONDRIAL_DYSFUNCTION([MITOCHONDRIAL DYSFUNCTION]) -->|"regulates"| FGF
    ASTROCYTE([ASTROCYTE]) -->|"regulates"| FGF
    ALZHEIMER([ALZHEIMER]) -->|"regulates"| FGF
    FGF2([FGF2]) -->|"interacts"| FGF

Outgoing (229)

Target	Relation	Type	Str
SOD1	activates	gene	0.70
SIRT1	activates	gene	0.70
SQSTM1	activates	gene	0.70
TFEB	activates	gene	0.70
SOD2	activates	gene	0.70
ULK1	activates	gene	0.70
NEURONS	transports	cell_type	0.70
TGF-beta signaling	participates_in	pathway	0.70
astrocytes	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
Fibrosis	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Glioblastoma	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
ALS	activates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
MTOR	regulates	gene	0.65
Inflammation	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Cancer	activates	disease	0.65
Neuroinflammation	activates	disease	0.65
Parkinson	activates	disease	0.65
CERS2	activates	gene	0.60
FGF7	activates	gene	0.60
FGFR2	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
CANCER	expressed_in	gene	0.60
FGF2	interacts_with	gene	0.60
ERK1	activates	gene	0.60
Angiogenesis	inhibits	pathway	0.60
Apoptosis	causes	pathway	0.60
AUTOPHAGY	activates	gene	0.60
P53	activates	protein	0.60
Fus	associated_with	protein	0.60
App	inhibits	protein	0.60
Ras	activates	protein	0.60
Als	therapeutic_target	disease	0.60
Cancer	interacts_with	disease	0.60
T Cell	regulates	cell_type	0.60
App	regulates	protein	0.60
FGF1	inhibits	gene	0.60
synaptic plasticity	participates_in	pathway	0.60

Incoming (281)

Source	Relation	Type	Str
ATG5	interacts_with	gene	0.70
ATG7	interacts_with	gene	0.70
ASTROCYTE	transports	cell_type	0.70
BDNF	biomarker_for	gene	0.60
VEGFA	biomarker_for	gene	0.60
GFAP	biomarker_for	gene	0.60
MDH1	biomarker_for	gene	0.60
CHI3L1	biomarker_for	gene	0.60
CYTOKINES	biomarker_for	gene	0.60
NPTX1	biomarker_for	gene	0.60
IL9	activates	gene	0.60
IL4	activates	gene	0.60
APOE	biomarker_for	gene	0.60
TAU	biomarker_for	gene	0.60
PDGFRB	biomarker_for	gene	0.60
AMYLOID-BETA	biomarker_for	gene	0.60
SQSTM1	biomarker_for	gene	0.60
NEFL	biomarker_for	gene	0.60
CHIT1	biomarker_for	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
EGR1	activates	gene	0.60
MTDNA	activates	gene	0.60
CGAS	activates	gene	0.60
CGAS-STING	inhibits	gene	0.60
RNA	activates	gene	0.60
AMPK	activates	gene	0.60
STING	activates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
MITOPHAGY	activates	gene	0.60
MICROGLIA	activates	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
GDNF	regulates	gene	0.60
VIMENTIN	expressed_in	gene	0.60
CREB	activates	gene	0.60
NURR1	activates	gene	0.60
CDK5R2	therapeutic_target	gene	0.60
SCN2B	therapeutic_target	gene	0.60
STAT1	therapeutic_target	gene	0.60
ISG15	therapeutic_target	gene	0.60
SCN8A	therapeutic_target	gene	0.60
GRM5	therapeutic_target	gene	0.60
SLC17A7	therapeutic_target	gene	0.60
FGF13	therapeutic_target	gene	0.60
ERK1	associated_with	gene	0.60
P38	associated_with	gene	0.60
LRRN1	regulates	gene	0.60
GSK3	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
PKC	associated_with	gene	0.60
NEURON	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGF in their description or question text

No additional research found

FGF

Understanding Entity Pages

Wiki Pages (21)

Neural Precursor Development

FGF10 — Fibroblast Growth Factor 10

FGF23 — Fibroblast Growth Factor 23

FGF Signaling Pathway in Neurodegeneration

FGF7 — Fibroblast Growth Factor 7

FGF Signaling in Parkinson's Disease

FGF6 Gene

FGF8 Gene

FGF21 — Fibroblast Growth Factor 21

FGF16 Gene

FGF13-MTCH2 Neuroprotection in Parkinson's Disease

FGF4 — Fibroblast Growth Factor 4

FGF-2 Protein (bFGF)

AD FGF/FGFR Signaling Companies

FGF17 Protein

FGFR3 - Fibroblast Growth Factor Receptor 3

PD FGF/FGFR Signaling Companies

FGF13 — Fibroblast Growth Factor 13

Fibroblast Growth Factor 21 (FGF21)

FGF14 — Fibroblast Growth Factor 14

FGF19 — Fibroblast Growth Factor 19