concept

FGF

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FGF: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

510Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	FGF
Key Genes/Proteins	Actin, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE, Amyloid
Related Diseases	Aging, ALS, Alzheimer
Related Pathways	Angiogenesis, Apoptosis, apoptosis pathway

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FGF["FGF"]
    style FGF fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    FGF -->|"regulates"| MTOR([MTOR])
    FGF -->|"regulates"| MYELINATION["MYELINATION"]
    FGF -->|"expressed in"| Cancer["Cancer"]
    FGF -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    FGF -->|"regulates"| Alzheimer["Alzheimer"]
    FGF -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    FGF -->|"regulates"| Inflammation["Inflammation"]
    DNA([DNA]) -->|"activates"| FGF
    FGF1([FGF1]) -->|"interacts"| FGF
    ERK1_2([ERK1/2]) -->|"activates"| FGF
    NEURODEGENERATION([NEURODEGENERATION]) -->|"regulates"| FGF
    EXERCISE([EXERCISE]) -->|"regulates"| FGF
    NEUROINFLAMMATION([NEUROINFLAMMATION]) -->|"regulates"| FGF
    MITOCHONDRIAL_DYSFUNCTION([MITOCHONDRIAL DYSFUNCTION]) -->|"regulates"| FGF
    ASTROCYTE([ASTROCYTE]) -->|"regulates"| FGF
    ALZHEIMER([ALZHEIMER]) -->|"regulates"| FGF
    FGF2([FGF2]) -->|"interacts"| FGF

Outgoing (229)

Target	Relation	Type	Str
SQSTM1	activates	gene	0.70
TFEB	activates	gene	0.70
NEURONS	transports	cell_type	0.70
SOD2	activates	gene	0.70
SOD1	activates	gene	0.70
SIRT1	activates	gene	0.70
ULK1	activates	gene	0.70
astrocytes	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
TGF-beta signaling	participates_in	pathway	0.70
Inflammation	regulates	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	activates	disease	0.65
Glioblastoma	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Aging	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
Cancer	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
Fibrosis	activates	disease	0.65
MTOR	regulates	gene	0.65
Neuroinflammation	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	activates	disease	0.65
Apoptosis	causes	pathway	0.60
Astrocyte	regulates	cell_type	0.60
Fibroblast	regulates	cell_type	0.60
FGF2	interacts_with	gene	0.60
TAU	regulates	gene	0.60
Fibroblast	interacts_with	cell_type	0.60
Stem Cell	contributes_to	cell_type	0.60
AMYLOID	regulates	gene	0.60
Angiogenesis	inhibits	pathway	0.60
CANCER	expressed_in	gene	0.60
Endothelial	activates	cell_type	0.60
NEURON	activates	gene	0.60
MTOR	associated_with	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
MANF	regulates	gene	0.60
SYNAPTOPHYSIN	activates	gene	0.60
REELIN	activates	gene	0.60
CCL5	associated_with	gene	0.60
CXCR4	activates	gene	0.60
AXON	associated_with	gene	0.60
Lipid Metabolism	regulates	pathway	0.60

Incoming (281)

Source	Relation	Type	Str
ASTROCYTE	transports	cell_type	0.70
ATG5	interacts_with	gene	0.70
ATG7	interacts_with	gene	0.70
CASP1	associated_with	gene	0.60
ALS	biomarker_for	gene	0.60
APOE	associated_with	gene	0.60
AGING	contributes_to	gene	0.60
EGF	associated_with	gene	0.60
FGF2	interacts_with	gene	0.60
ASTROCYTE	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
PARKINSON	activates	gene	0.60
BCL-2	regulates	gene	0.60
LGALS9	regulates	gene	0.60
EPOR	regulates	gene	0.60
STAT1	regulates	gene	0.60
ISG15	regulates	gene	0.60
P38	regulates	gene	0.60
TLR4	regulates	gene	0.60
ERK	regulates	gene	0.60
CXCL10	regulates	gene	0.60
EPO	regulates	gene	0.60
CSF2	regulates	gene	0.60
MAPK	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
NAD	regulates	gene	0.60
AMPK	regulates	gene	0.60
FGF21	regulates	gene	0.60
MTORC1	regulates	gene	0.60
AGING	regulates	gene	0.60
SOD1	activates	gene	0.60
SOD2	activates	gene	0.60
NOX4	activates	gene	0.60
FGFR1	activates	gene	0.60
CATHEPSIN-B	activates	gene	0.60
CYTOKINES	activates	gene	0.60
IGF-1	activates	gene	0.60
AGING	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
NLRP3	associated_with	gene	0.60
FGF2	associated_with	gene	0.60
IL13	associated_with	gene	0.60
ICAM1	associated_with	gene	0.60
RAS	expressed_in	gene	0.60
HIF1A	associated_with	gene	0.60
PPAR	associated_with	gene	0.60
MIRNAS	expressed_in	gene	0.60
IRS1	associated_with	gene	0.60
MRC1	associated_with	gene	0.60
PPARG	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FGF in their description or question text

No additional research found

FGF

Understanding Entity Pages

Wiki Pages (21)

Neural Precursor Development

FGF10 — Fibroblast Growth Factor 10

FGF23 — Fibroblast Growth Factor 23

FGF Signaling Pathway in Neurodegeneration

FGF7 — Fibroblast Growth Factor 7

FGF Signaling in Parkinson's Disease

FGF6 Gene

FGF8 Gene

FGF21 — Fibroblast Growth Factor 21

FGF16 Gene

FGF13-MTCH2 Neuroprotection in Parkinson's Disease

FGF4 — Fibroblast Growth Factor 4

FGF-2 Protein (bFGF)

AD FGF/FGFR Signaling Companies

FGF17 Protein

FGFR3 - Fibroblast Growth Factor Receptor 3

PD FGF/FGFR Signaling Companies

FGF13 — Fibroblast Growth Factor 13

Fibroblast Growth Factor 21 (FGF21)

FGF14 — Fibroblast Growth Factor 14

FGF19 — Fibroblast Growth Factor 19