mechanism 1,097 words KG: ent-gene-c80bcf41 2026-04-01
kind:mechanismsection:mechanismsstate:publishedtopic:alzheimerstopic:microgliatopic:causal-chainstopic:geneticstopic:therapeutics
Contents

INPP5D SHIP1 Dysfunction Alzheimer's Disease Causal Chain

🔬 Protein Info
Gene SymbolINPP5D
Full NameInositol Polyphosphate-5-Phosphatase D (SHIP1)
AliasesSHIP1
Chromosome2q37.1
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionhematopoietic cells and microglia
Molecular Weight145 kDa
Amino Acids1190 aa
Exons13
PathwaysPI3K, mTOR, mtor, NF-κB
Ensembl IDENSG00000168918
GeneCardsINPP5D
Human Protein AtlasINPP5D
ProteinSHIP1 (SH2-containing Inositol 5'-Phosphatase 1)
GWAS Locus2q37.1 (rs35349682, rs10988217)
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, Ms
InteractionsAPOE, RIPK1, MYD88, NLRP3, TDP-43, ZBP1
KG Connections393 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.66
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.59
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52

Related Analyses (30)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Cell type vulnerability in Alzheimers Disease (SEA-AD transc
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.95
CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90
s:** - Test whether HCN1 knockout specifically in EC layer I
falsification · proposed · Score: 0.40

See Also (15)

Vascular Dementia Mechanisms — Overlap with Alzheimer's
mechanism · Pages share 18 hypotheses
Ubiquitin-Proteasome System Dysfunction in Alzheimer's
mechanism · Pages share 18 hypotheses
Tau Kinase Signaling Cascade in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Tau Kinase-Phosphatase Balance in Alzheimer's Disease
mechanism · Pages share 18 hypotheses
Synaptic Loss in Alzheimer's Disease Pathway
mechanism · Pages share 18 hypotheses