| Gene Symbol | ADRA2A |
| Aliases | ADRA2APROTEIN |
| Target Class | Gpcr |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Mechanism of Action | Small molecule agonists and antagonists modulating noradrenergic signaling |
| Druggability | Medium (0.59) |
| Clinical Stage | Approved |
| GeneCards | ADRA2A |
| Human Protein Atlas | ADRA2A |
| 7 transmembrane domains | Classic GPCR structure |
| N-terminal extracellular domain | Glycosylation sites |
| C-terminal intracellular domain | G protein coupling |
| Disulfide bonds | Extracellular domain stabilization |
| Orthosteric site | Binds catecholamines (norepinephrine, epinephrine) |
| Allosteric sites | Modulator binding pockets |
| Associated Diseases | Als, Alzheimer, Alzheimer's disease |
| Known Drugs/Compounds | mirtazapine |
| Interactions | ADRA1A, ADRA2B, ADRB1, ALDH1A2, CTSD, DBH |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Noradrenergic-Tau Propagation Blockade |
| KG Connections | 223 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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