Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adrb1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADRB1 |
| Full Name | Beta-1 Adrenergic Receptor |
| Chromosome | 10q25.3 |
| Function | regulator of cardiac and neuronal function |
| Primary Expression | key regions involved in cognition, arousal, and autonomic regulation, making it relevant to neurodegenerative diseases including [Alzheimer's disease] |
| Amino Acids | 477 aa |
| UniProt ID | P08588 |
| NCBI Gene ID | 153 |
| Ensembl ID | ENSG00000143578 |
| OMIM | 109630 |
| GeneCards | ADRB1 |
| Human Protein Atlas | ADRB1 |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["ADRB1"]
N1["AGING"]
N0 -->|"therapeutic target"| N1
N2["CPT2"]
N0 -->|"associated with"| N2
N3["CPT1A"]
N0 -->|"associated with"| N3
N4["CACNA2D2"]
N0 -->|"associated with"| N4
N5["Rb"]
N0 -->|"associated with"| N5
N6["CDH1"]
N6 -->|"therapeutic target"| N0
N7["PER"]
N7 -->|"therapeutic target"| N0
N8["CACNB3"]
N8 -->|"associated with"| N0
N9["neurodegeneration"]
N0 -->|"implicated in"| N9
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 gene
class N2 gene
class N3 gene
class N4 gene
class N5 protein
class N6 gene
class N7 gene
class N8 gene| Target | Relation | Type | Str |
|---|---|---|---|
| CPT2 | associated_with | gene | 0.60 |
| CACNA2D2 | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| DBH | interacts_with | gene | 0.60 |
| ERBB4 | interacts_with | gene | 0.60 |
| IL1RL1 | interacts_with | gene | 0.60 |
| IL33 | interacts_with | gene | 0.60 |
| NRG1 | interacts_with | gene | 0.60 |
| AGING | therapeutic_target | gene | 0.60 |
| CPT1A | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:ADRB1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||