protein 998 words KG: APOC3PROTEIN 2026-03-30
kind:proteinsection:proteinsstate:published
Contents

APOC3 Protein

🔬 Protein Info
Gene SymbolAPOC3
Full NameApolipoprotein C-III
AliasesApoC-III, APOC3
Chromosome11q23.3
Protein FamilyApolipoprotein C family
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionHepatocytes in the liver (highest expression)
Subcellular LocalizationSecreted, plasma lipoprotein particles
Molecular Weight8.8 kDa
Amino Acids79 aa
PathwaysCholesterol
UniProt IDP02656
NCBI Gene ID345
Ensembl IDENSG00000110245
GeneCardsAPOC3
Human Protein AtlasAPOC3
Associated DiseasesAging, Als, Atherosclerosis, Cardiovascular
InteractionsAPOA1, APOE, ABCA1, APOC1, ABCA2, APOC2
KG Connections100 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.49
APOE Isoform Expression Across Glial Subtypes
Score: 0.48
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in