protein 506 words KG: ARF1 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

ARF1 Protein

🔬 Protein Info
Gene SymbolARF1
Protein FamilyARF GTPase family
Functionis a small GTP-binding protein that functions as a molecular switch regulating vesicle trafficking between the endoplasmic reticulum (ER) and the Golgi apparatus.
Subcellular LocalizationGolgi apparatus, ER-Golgi intermediate compartment
Molecular Weight20.7 kDa
Amino Acids181 aa
UniProt ID[P84077](https://www.uniprot.org/uniprot/P84077)
GeneCardsARF1
Human Protein AtlasARF1
Associated Diseasesneurodegeneration
InteractionsRHOA, GCLC, SCARB2, Rb, MITOCHONDRIA, AND
KG Connections76 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

APOE-Dependent Autophagy Restoration
Score: 0.61
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
LRP1-Dependent Tau Uptake Disruption
Score: 0.44
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.41

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Glycolysis Metabolism in Neurodegeneration
mechanism · KG edge: inhibits
Fibroblast Growth Factor Signaling in Neurodegeneration
mechanism · KG edge: activates
Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: activates
LRP1-Enhanced Perivascular Drainage Therapy
idea · KG edge: activates
gclc
gene · KG edge: activates

Knowledge Graph (12 edges)

ARF1 inhibits RHOA
ARF1 activates RHOA
ARF1 activates LRP1
ARF1 inhibits LRP1
ARF1 activates GCLC
ARF1 activates mTORC1
ARF1 activates MTOR
ARF1 activates SCARB2
ARF1 activates Rb
ARF1 expressed_in ATG7