| Gene Symbol | LRP1 |
| Aliases | Low-density lipoprotein receptor-related protein 1, CD91 |
| Protein Type | Receptor |
| Target Class | Receptor |
| Function | In the healthy nervous system, LRP1 functions as |
| Mechanism of Action | Modulation of receptor-mediated endocytosis and clearance pathways |
| Druggability | Low (0.39) |
| Clinical Stage | Phase III |
| Molecular Weight | 600 kDa |
| Amino Acids | 525 aa |
| Pathways | Aβ clearance, APOE trafficking, Endocytosis, MAPK, PI3K |
| UniProt ID | Q07954 |
| GeneCards | LRP1 |
| Human Protein Atlas | LRP1 |
| Lipoprotein receptors | Binds LDL, VLDL, and apolipoprotein E (ApoE)-containing lipoproteins |
| Associated Diseases | ALS, Aging, Alzheimer, Alzheimer'S Disease |
| Known Drugs/Compounds | MELATONIN |
| Interactions | TFR1, CAV1, ABCB1, MTNR1A, MTNR1B, APOE |
| SciDEX Target | View Target Profile (6 clinical trials) |
| SciDEX Hypotheses | LRP1-Dependent Tau Uptake Disruption |
| KG Connections | 1509 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |