gene 863 words KG: SCARB2 2026-03-21
kind:genesection:genesstate:published
Contents

SCARB2 Gene

🧬 Gene Info
Gene SymbolSCARB2
FunctionSCARB2/LIMP-2 encodes a highly glycosylated type I transmembrane protein that serves multiple functions:
Subcellular Localization- Lysosomal membranes
PathwaysAutophagy, Mitochondrial Function, Mtor, Cholesterol, Alpha-Synuclein
GeneCardsSCARB2
Human Protein AtlasSCARB2
Associated DiseasesAls, Ms, REM sleep behavior disorder, Synucleinopathy
Known Drugs/CompoundsGlutathione
InteractionsARF1, GCLC, LIPA, SLC17A5, GNPTAB, SMPD1
KG Connections98 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (4)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.45
Lysosomal Positioning Dynamics Modulation
Score: 0.43

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (13)

Glutathione Metabolism Pathway
mechanism · KG edge: binds
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: activates
Packard Center for ALS Research
institution · KG edge: activates
LIPA Gene
gene · KG edge: activates
GNPTAB — N-Acetylglucosamine-1-Phosphate Transferase Al
gene · KG edge: activates

Knowledge Graph (12 edges)

SCARB2 associated_with REM sleep behavior disorder
SCARB2 expressed_in SNCA-AS1
SCARB2 associated_with TMEM175
SCARB2 associated_with UBE2D1
SCARB2 associated_with LGALS1
SCARB2 associated_with CALCOCO2
SCARB2 associated_with CDKN1A
SCARB2 associated_with NPC1
SCARB2 activates ARF1
SCARB2 activates GCLC