gene 2,670 words KG: RHOA 2026-03-27
kind:genesection:genesstate:publishedtopic:gtpasetopic:cytoskeletontopic:synaptic-plasticitytopic:neurodegenerationtopic:signal-transduction
Contents

RHOA Gene — Ras Homolog Family Member A

🧬 Gene Info
Gene SymbolRHOA
Full NameRas Homolog Family Member A
Chromosome3p21.31
Functionencodes a small GTP-binding protein that functions as a molecular switch, cycling between an active GTP-bound state and an inactive GDP-bound state.
Molecular Weight~22 kDa
Amino Acids191 aa
PathwaysAkt, Angiogenesis, Apoptosis, Complement, Egfr Signaling
UniProt ID[P61586](https://www.uniprot.org/uniprotkb/P61586/entry)
Ensembl IDENSG00000167553
GeneCardsRHOA
Human Protein AtlasRHOA
Associated DiseasesAlzheimer, Dementia, Lung Cancer, Ms, TUMOR
InteractionsARF1, ROCK1, BMAL1, APP, CDC42, TP53
KG Connections357 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (17)

Microglial Purinergic Reprogramming
Score: 0.48
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44
Complement C1q Subtype Switching
Score: 0.44
Ephrin-B2/EphB4 Axis Manipulation
Score: 0.40
Netrin-1 Gradient Restoration
Score: 0.33

Related Analyses (7)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: expressed_in
Alzheimer Indonesia
institution · KG edge: inhibits
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: inhibits
ARHGEF2 Gene
gene · KG edge: activates
ARF1 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

RHOA inhibits ARF1
RHOA regulates TFEB
RHOA regulates APP
RHOA regulates SQSTM1
RHOA activates ROCK1
RHOA inhibits BMAL1
RHOA expressed_in ARNT
RHOA associated_with EGFR
RHOA associated_with CALM1
RHOA associated_with ACTB