| Gene Symbol | BAG2 |
| Protein Type | Chaperone |
| Function | BAG2 (BCL2 Associated Athanogene 2) is a co-chaperone protein that modulates the Hsp70/Hsp90 chaperone systems. |
| Subcellular Localization | </strong></td><td>Cytoplasm, Nucleus (minor)</td></tr> |
| Molecular Weight | 22.5 kDa |
| Amino Acids | 211 aa |
| Pathways | Proteasome |
| Ensembl ID | ENSG00000165168 |
| GeneCards | BAG2 |
| Human Protein Atlas | BAG2 |
| ATPase Inhibition | Binds to Hsp70 ATPase domain, blocking substrate binding and release |
| Chaperone Complex Assembly | Forms ternary complexes with Hsp70 and client proteins |
| Protein Quality Control | Modulates the balance between refolding and degradation pathways |
| Protein Turnover | Influences the fate of misfolded proteins |
| Direct Tau Binding | BAG2 directly interacts with tau protein through its N-terminal region |
| Associated Diseases | Ms |
| Interactions | AUTOPHAGY, P62, SQSTM1, TAU, UBIQUITIN |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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